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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Diseases and Injuries Collaborators. GBD 2021 Diseases and Injuries Collaborators. Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print. Lancet. 2024. PMID: 38642570
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset.
Budding K, Bos JW, Dijkxhoorn K, de Zeeuw E, Bloemenkamp LM, Zekveld EM, Groen EJN, Jacobs BC, Huizinga R, Goedee HS, Cats EA, Leusen JHW, van den Berg LH, Hack CE, van der Pol WL. Budding K, et al. J Neuroinflammation. 2024 Apr 17;21(1):100. doi: 10.1186/s12974-024-03090-y. J Neuroinflammation. 2024. PMID: 38632654 Free PMC article.
IgM anti-GM2 binding to SCs correlated with complement activation, as reflected by increased C3 fixation on SCs and C5a formation in the supernatant. CONCLUSION: Circulating IgM anti-GM2 antibodies define a subgroup of patients with MMN that has an earlier onset of disease …
IgM anti-GM2 binding to SCs correlated with complement activation, as reflected by increased C3 fixation on SCs and C5a formation in …
Complement propagates visual system pathology following traumatic brain injury.
Borucki DM, Rohrer B, Tomlinson S. Borucki DM, et al. J Neuroinflammation. 2024 Apr 17;21(1):98. doi: 10.1186/s12974-024-03098-4. J Neuroinflammation. 2024. PMID: 38632569 Free PMC article.
To investigate the role of complement, cohorts were treated after TBI with the complement inhibitor, CR2-Crry. RESULTS: At 3 days after TBI, complement component C3 was deposited on retinogeniculate synapses in the dLGN both ipsilateral and contralateral to the lesion, whi …
To investigate the role of complement, cohorts were treated after TBI with the complement inhibitor, CR2-Crry. RESULTS: At 3 days after TBI, …
Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice.
Jash A, Pridmore T, Collins JB, Hay AM, Hudson KE, Luckey CJ, Zimring JC. Jash A, et al. J Clin Invest. 2024 Apr 15;134(8):e167665. doi: 10.1172/JCI167665. J Clin Invest. 2024. PMID: 38618959 Free PMC article.
Recent advances in mechanistic understanding have demonstrated that RBC alloimmunization requires the IFN-alpha/-beta receptor (IFNAR) and is inhibited by the complement C3 protein. Here, we demonstrate the opposite for AMIE of an RBC alloantigen (IFNAR is not required and …
Recent advances in mechanistic understanding have demonstrated that RBC alloimmunization requires the IFN-alpha/-beta receptor (IFNAR) and i …
Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study.
Fan Y, Moser J, van Meurs M, Kiers D, Sand JMB, Leeming DJ, Pickkers P, Burgess JK, Kox M, Pillay J. Fan Y, et al. Crit Care. 2024 Apr 12;28(1):120. doi: 10.1186/s13054-024-04904-4. Crit Care. 2024. PMID: 38609959 Free PMC article.
Circulating neo-epitopes of extracellular matrix turnover, including ECM degradation neo-epitopes of collagen type I (C1M), type III (C3M), type IV (C4Ma3), and type VI (C6M), elastin (ELP-3) and fibrin (X-FIB), as well as the ECM synthesis neo-epitopes of collagen type III (PRO- …
Circulating neo-epitopes of extracellular matrix turnover, including ECM degradation neo-epitopes of collagen type I (C1M), type III (C3M), …
Japanese spotted fever complicated by acute sensorineural hearing loss.
Shingu M, Fujishima C, Hara S, Nishioka H. Shingu M, et al. J Infect Chemother. 2024 Apr 9:S1341-321X(24)00104-1. doi: 10.1016/j.jiac.2024.03.020. Online ahead of print. J Infect Chemother. 2024. PMID: 38599283
Pure-tone audiometry revealed bilateral sensorineural hearing loss, and a skin biopsy revealed leukocytoclastic vasculitis with deposition of C3 and IgM on the vessel walls. Under the tentative diagnosis of rickettsiosis, scrub typhus, or Japanese spotted fever, the patien …
Pure-tone audiometry revealed bilateral sensorineural hearing loss, and a skin biopsy revealed leukocytoclastic vasculitis with deposition o …
Design of a flow modulation device to facilitate individualized ventilation in a shared ventilator setup.
Stiers M, Vercauteren J, Schepens T, Mergeay M, Janssen L, Hoogmartens O, Neyrinck A, Marinus BG, Sabbe M. Stiers M, et al. J Clin Monit Comput. 2024 Apr 1. doi: 10.1007/s10877-024-01138-1. Online ahead of print. J Clin Monit Comput. 2024. PMID: 38557919
The ventilation parameters: VT and airway pressures, and ventilation profiles: pressure, flow and volume were measured for different ventilator and device settings for a healthy and ARDS simulated lung pathology. We obtained VTs with a linear correlation with valve opening …
The ventilation parameters: VT and airway pressures, and ventilation profiles: pressure, flow and volume were measured for different ventila …
Effect of total flavonoids of Dracocephalum moldavica L. On neuroinflammation in Alzheimer's disease model amyloid-β (Aβ1-42)-peptide-induced astrocyte activation.
Ren W, Yan XS, Fan JC, Huo DS, Wang XX, Jia JX, Yang ZJ. Ren W, et al. J Toxicol Environ Health A. 2024 May 18;87(10):436-447. doi: 10.1080/15287394.2024.2336570. Epub 2024 Apr 1. J Toxicol Environ Health A. 2024. PMID: 38557424
Western blotting and ELISA were used to determine the expression of glial fibrillary acidic protein (GFAP), and complement C3 to establish the activation status of astrocytes following induction from exposure to Abeta1-42. Data demonstrated that stimulation of C8-D1A astro …
Western blotting and ELISA were used to determine the expression of glial fibrillary acidic protein (GFAP), and complement C3 to esta …
Obese patients with CEAP (clinical, etiology, anatomy, pathophysiology) C2 and C3 disease show enhanced symptom improvement after endovenous thermal ablation.
Zottola ZR, Geiger JT, Choo GE, Kedwai BJ, Balceniuk MD, Ellis JL, Doyle AJ, Newhall KA. Zottola ZR, et al. J Vasc Surg Venous Lymphat Disord. 2024 Mar 19:101873. doi: 10.1016/j.jvsv.2024.101873. Online ahead of print. J Vasc Surg Venous Lymphat Disord. 2024. PMID: 38513798 Free article.
However, the decision to intervene for patients with less severe disease (CEAP [clinical, etiology, anatomy, pathophysiology] C2 and C3) is less clear and becomes further complicated for patients with obesity, a pathology known to increase venous disease symptom sev …
However, the decision to intervene for patients with less severe disease (CEAP [clinical, etiology, anatomy, pathophysiology] C2 and C3 …
4,831 results