MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus.
Wang T, Song D, Li X, Luo Y, Yang D, Liu X, Kong X, Xing Y, Bi S, Zhang Y, Hu T, Zhang Y, Dai S, Shao Z, Chen D, Hou J, Ballestar E, Cai J, Zheng F, Yang JY.
Wang T, et al.
Cell Commun Signal. 2024 Apr 8;22(1):220. doi: 10.1186/s12964-024-01601-1.
Cell Commun Signal. 2024.
PMID: 38589923
Free PMC article.
In a transgenic mouse model, the induction of miR-574-5p overexpression is associated with increased secretion of antinuclear and anti-dsDNA antibodies, increased IgG and C3 deposit in the kidney, elevated expression of inflammatory genes in the spleen. ...
In a transgenic mouse model, the induction of miR-574-5p overexpression is associated with increased secretion of antinuclear and anti-dsDNA …