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Effect of fluoroquinolones on mitochondrial function in pancreatic beta cells.
Ghaly H, Jörns A, Rustenbeck I. Ghaly H, et al. Eur J Pharm Sci. 2014 Feb 14;52:206-14. doi: 10.1016/j.ejps.2013.11.011. Epub 2013 Nov 24. Eur J Pharm Sci. 2014. PMID: 24284031
Hyper- and hypoglycaemias are known side effects of fluoroquinolone antibiotics, resulting in a number of fatalities. Fluoroquinolone-induced hypoglycaemias are due to stimulated insulin release by the inhibition of the KATP channel activity of the beta cell. ...
Hyper- and hypoglycaemias are known side effects of fluoroquinolone antibiotics, resulting in a number of fatalities. Fluoroquinolone …
Immunocytochemical and ultrastructural heterogeneities of normal and glibenclamide stimulated pancreatic beta cells in the rat.
Jörns A. Jörns A. Virchows Arch. 1994;425(3):305-13. doi: 10.1007/BF00196154. Virchows Arch. 1994. PMID: 7812517
Beta cells in small islets and at extra-islet sites exhibited a dense immunoreactivity. After administration of glibenclamide, immunoreactivities for insulin and amylin were diminished in a time-dependent manner, decreasing first in medullary and thereafter in corti …
Beta cells in small islets and at extra-islet sites exhibited a dense immunoreactivity. After administration of glibenclamide, immuno …
Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells.
Cetin Y, Aunis D, Bader MF, Galindo E, Jörns A, Bargsten G, Grube D. Cetin Y, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2360-4. doi: 10.1073/pnas.90.6.2360. Proc Natl Acad Sci U S A. 1993. PMID: 8096340 Free PMC article.
Chromogranin A (CGA) is a secretory protein present in the adrenal medulla and in a variety of endocrine organs. This protein may serve as precursor for pancreastatin (PST) and for other biologically active peptides. Recently, chromostatin (CST), a CGA …
Chromogranin A (CGA) is a secretory protein present in the adrenal medulla and in a variety of endocrine organs. This p …
Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters.
Jörns A, Tiedge M, Sickel E, Lenzen S. Jörns A, et al. Virchows Arch. 1996 Jun;428(3):177-85. doi: 10.1007/BF00200660. Virchows Arch. 1996. PMID: 8688972
The diabetic Chinese hamster is a well-established animal model for NIDDM with a defective glucose-induced insulin secretory response. ...GLUT2 immunoreactivity was already significantly reduced in beta cells from mildly diabetic animals in spite of a normal …
The diabetic Chinese hamster is a well-established animal model for NIDDM with a defective glucose-induced insulin secretory r …
Insulin and GLUT2 glucose transporter immunoreactivity in B-cells of whole pancreas isografts and allografts in the streptozotocin-diabetic rat.
Jörns A, Klempnauer J. Jörns A, et al. Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:103-6. doi: 10.1055/s-0029-1211404. Exp Clin Endocrinol Diabetes. 1995. PMID: 8839264
Interestingly, B-cells in the allografts with a dense insulin immunoreactivity exhibited GLUT2 glucose transporter expression in both localizations, whereas B-cells with a faint insulin immunoreactivity exhibited GLUT2 glucose transporter only in the plasma membrane …
Interestingly, B-cells in the allografts with a dense insulin immunoreactivity exhibited GLUT2 glucose transporter expression in both …
Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro.
Jörns A, Munday R, Tiedge M, Lenzen S. Jörns A, et al. J Endocrinol. 1997 Nov;155(2):283-93. doi: 10.1677/joe.0.1550283. J Endocrinol. 1997. PMID: 9415063
The effect of alloxan has been compared with that of a number of N-alkyl alloxan derivatives and with that of the structurally related compound, ninhydrin. ...Since 3-O-methylglucose is known to prevent uptake of alloxan by pancreatic beta cells, it appears that uptake of …
The effect of alloxan has been compared with that of a number of N-alkyl alloxan derivatives and with that of the structurally relate …
Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells.
Jörns A, Tiedge M, Lenzen S. Jörns A, et al. Virchows Arch. 1999 Jan;434(1):75-82. doi: 10.1007/s004280050308. Virchows Arch. 1999. PMID: 10071239
In the pericapillary space beta cell glucokinase immunoreactivity had a polar orientation, with the highest density in cytoplasmic regions close to the blood vessels. Starvation resulted in a loss of heterogeneity with homogeneous insulin staining in all beta cells …
In the pericapillary space beta cell glucokinase immunoreactivity had a polar orientation, with the highest density in cytoplasmic re …
Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro.
Jörns A, Tiedge M, Lenzen S, Munday R. Jörns A, et al. Free Radic Biol Med. 1999 May;26(9-10):1300-4. doi: 10.1016/s0891-5849(98)00325-6. Free Radic Biol Med. 1999. PMID: 10381203
The results indicate a role for superoxide radical and hydrogen peroxide in the mechanism of toxicity of alloxan but do not support the involvement of the hydroxyl radical in this process. ...
The results indicate a role for superoxide radical and hydrogen peroxide in the mechanism of toxicity of alloxan but do not support t …
Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats.
Jörns A, Klempnauer J, Tiedge M, Lenzen S. Jörns A, et al. Pancreas. 2001 Aug;23(2):186-96. doi: 10.1097/00006676-200108000-00009. Pancreas. 2001. PMID: 11484921
In the diabetic state the pancreatic beta cells displayed a weak immunostaining for insulin and glucokinase together with a lack of GLUT2 glucose transporter immunoreactivity in the plasma membrane. ...Pancreatic beta cells can function properly in a diabetic …
In the diabetic state the pancreatic beta cells displayed a weak immunostaining for insulin and glucokinase together with a la …
Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies.
Rustenbeck I, Winkler M, Jörns A. Rustenbeck I, et al. Biochem Pharmacol. 2001 Dec 15;62(12):1685-94. doi: 10.1016/s0006-2952(01)00792-4. Biochem Pharmacol. 2001. PMID: 11755122
A long-term depolarization with 40 mM KCl was also able to induce a significant reduction of the secretory response to all of the above secretagogues. ...In contrast to these observations, the ultrastructural examination revealed that tolbutamide-treated B-cells had
A long-term depolarization with 40 mM KCl was also able to induce a significant reduction of the secretory response to all of
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