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The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2.
Wagner MJ, Hsiung MS, Gish GD, Bagshaw RD, Doodnauth SA, Soliman MA, Jørgensen C, Tucholska M, Rottapel R. Wagner MJ, et al. J Biol Chem. 2020 Mar 20;295(12):3932-3944. doi: 10.1074/jbc.RA119.009276. Epub 2020 Feb 14. J Biol Chem. 2020. PMID: 32060095