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Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate binding site.
Martinelli L, Adamopoulos A, Johansson P, Wan PT, Gunnarsson J, Guo H, Boyd H, Zelcer N, Sixma TK. Martinelli L, et al. J Biol Chem. 2020 Jul 29:jbc.RA120.014349. doi: 10.1074/jbc.RA120.014349. Online ahead of print. J Biol Chem. 2020. PMID: 32727844
Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction.
Banerjee S, Ghoshal S, Stevens JR, McCommis KS, Gao S, Castro-Sepulveda M, Mizgier ML, Girardet C, Kumar KG, Galgani JE, Niehoff ML, Farr SA, Zhang J, Butler AA. Banerjee S, et al. J Biol Chem. 2020 Jul 29:jbc.RA120.014381. doi: 10.1074/jbc.RA120.014381. Online ahead of print. J Biol Chem. 2020. PMID: 32727846
Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library.
Parray HA, Chiranjivi AK, Asthana S, Yadav N, Shrivastava T, Mani S, Sharma C, Vishwakarma P, Das S, Pindari K, Sinha S, Samal S, Ahmed S, Kumar R. Parray HA, et al. J Biol Chem. 2020 Jul 29:jbc.AC120.014918. doi: 10.1074/jbc.AC120.014918. Online ahead of print. J Biol Chem. 2020. PMID: 32727845
Cation channel conductance and pH gating of the innate immunity factor APOL1 is governed by pore lining residues within the C-terminal domain.
Schaub C, Verdi J, Lee P, Terra N, Limon G, Raper J, Thomson R. Schaub C, et al. J Biol Chem. 2020 Jul 29:jbc.RA120.014201. doi: 10.1074/jbc.RA120.014201. Online ahead of print. J Biol Chem. 2020. PMID: 32727852
15-keto-PGE2acts as a biased/partial agonist to terminate PGE2-evoked signaling.
Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H. Endo S, et al. J Biol Chem. 2020 Jul 29:jbc.RA120.013988. doi: 10.1074/jbc.RA120.013988. Online ahead of print. J Biol Chem. 2020. PMID: 32727851
Molecular determinants of Release Factor 2 for ArfA-mediated ribosome rescue.
Kurita D, Abo T, Himeno H. Kurita D, et al. J Biol Chem. 2020 Jul 28:jbc.RA120.014664. doi: 10.1074/jbc.RA120.014664. Online ahead of print. J Biol Chem. 2020. PMID: 32727848
Lysosome-targeted β-galactosidase negatively regulates neuraminidase 1 (NEU1) and promotes NEU1 deficiency in GM1 gangliosidosis.
Luu AR, Wong H, Agrawal V, Wise N, Handyside B, Lo MJ, Pacheco G, Felix JB, Giaramita A, d'Azzo A, Vincelette J, Bullens S, Bunting S, Christianson TM, Hague C, Lebowitz JH, Yogalingam G. Luu AR, et al. J Biol Chem. 2020 Jul 28:jbc.RA119.010794. doi: 10.1074/jbc.RA119.010794. Online ahead of print. J Biol Chem. 2020. PMID: 32727849
EGFR forms ligand-independent oligomers that are distinct from the active state.
Byrne PO, Hristova K, Leahy DJ. Byrne PO, et al. J Biol Chem. 2020 Jul 29:jbc.RA120.012852. doi: 10.1074/jbc.RA120.012852. Online ahead of print. J Biol Chem. 2020. PMID: 32727847
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