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A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling.
Li S, Jiang L, Beckmann K, Højen JF, Pessara U, Powers NE, de Graaf DM, Azam T, Lindenberger J, Eisenmesser EZ, Fischer S, Dinarello CA. Li S, et al. J Biol Chem. 2021 Apr 3:100630. doi: 10.1016/j.jbc.2021.100630. Online ahead of print. J Biol Chem. 2021. PMID: 33823154 Free PMC article.
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Vilalta A, Zhou Y, Sevalle J, Griffin JK, Satoh K, Allendorf DH, De S, Puigdellívol M, Bruzas A, Burguillos MA, Dodd RB, Chen F, Zhang Y, Flagmeier P, Needham LM, Enomoto M, Qamar S, Henderson J, Walter J, Fraser PE, Klenerman D, Lee SF, St George-Hyslop P, Brown GC. Vilalta A, et al. J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631. Online ahead of print. J Biol Chem. 2021. PMID: 33823153 Free article.
A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.
Horn IP, Marks DL, Koenig AN, Hogenson TL, Almada LL, Goldstein LE, Romecin Duran PA, Vera R, Vrabel AM, Cui G, Rabe KG, Bamlet WR, Mer G, Sicotte H, Zhang C, Li H, Petersen GM, Fernandez-Zapico ME. Horn IP, et al. J Biol Chem. 2021 Apr 3:100634. doi: 10.1016/j.jbc.2021.100634. Online ahead of print. J Biol Chem. 2021. PMID: 33823155 Free article.