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Year Number of Results
1994 1
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15 results

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Page 1
Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.
Sabat M, Carney DW, Hernandez-Torres G, Gibson TS, Balakrishna D, Zou H, Xu R, Chen CH, de Jong R, Dougan DR, Qin L, Bigi-Botterill SV, Chambers A, Miura J, Johnson LK, Ermolieff J, Johns D, Selimkhanov J, Kwok L, DeMent K, Proffitt C, Vu P, Lindsey EA, Ivetac T, Jennings A, Wang H, Manam P, Santos C, Fullenwider C, Manohar R, Flick AC. Sabat M, et al. Among authors: ermolieff j. J Med Chem. 2024 Jun 27;67(12):10306-10320. doi: 10.1021/acs.jmedchem.4c00743. Epub 2024 Jun 13. J Med Chem. 2024. PMID: 38872300
Correction to "Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design".
Sabat M, Dougan DR, Ermolieff J, Halkowycz P, Knight B, Lawson JD, Scorah N, Smith CR, Taylor ER, Vu P, Wyrick C, Wang H, Balakrishna D, Hixon M, Madakamutil L, McConn D. Sabat M, et al. Among authors: ermolieff j. J Med Chem. 2021 Nov 11;64(21):16318. doi: 10.1021/acs.jmedchem.1c01685. Epub 2021 Oct 28. J Med Chem. 2021. PMID: 34708652 No abstract available.
Heparin accelerates the inhibition of cathepsin G by mucus proteinase inhibitor: potent effect of O-butyrylated heparin.
Ermolieff J, Duranton J, Petitou M, Bieth JG. Ermolieff J, et al. Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1369-74. doi: 10.1042/bj3301369. Biochem J. 1998. PMID: 9494108 Free PMC article.
Heparin tightly binds cathepsin G and so protects the enzyme from inhibition by alpha1-antichymotrypsin, alpha1-proteinase inhibitor and eglin c, three proteins which do not bind heparin [Ermolieff J., Boudier C., Laine A., Meyer B. and Bieth J.G. (1994) J. B …
Heparin tightly binds cathepsin G and so protects the enzyme from inhibition by alpha1-antichymotrypsin, alpha1-proteinase inhibitor and egl …
Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Murphy ST, Alton G, Bailey S, Baxi SM, Burke BJ, Chappie TA, Ermolieff J, Ferre R, Greasley S, Hickey M, Humphrey J, Kablaoui N, Kath J, Kazmirski S, Kraus M, Kupchinsky S, Li J, Lingardo L, Marx MA, Richter D, Tanis SP, Tran K, Vernier W, Xie Z, Yin MJ, Yu XH. Murphy ST, et al. Among authors: ermolieff j. J Med Chem. 2011 Dec 22;54(24):8490-500. doi: 10.1021/jm201019k. Epub 2011 Nov 23. J Med Chem. 2011. PMID: 22040023
Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).
Ghosh AK, Shin D, Downs D, Koelsch G, Lin X, Ermolieff J, Tang J. Ghosh AK, et al. Among authors: ermolieff j. J Am Chem Soc. 2000 Apr 12;122(14):3522-3523. doi: 10.1021/ja000300g. Epub 2000 Mar 23. J Am Chem Soc. 2000. PMID: 30443047 Free PMC article. No abstract available.
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.
Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J. Turner RT 3rd, et al. Among authors: ermolieff j. Biochemistry. 2001 Aug 28;40(34):10001-6. doi: 10.1021/bi015546s. Biochemistry. 2001. PMID: 11513577
A molecular model of OM00-3 binding to memapsin 2 revealed critical improvement of the interactions between inhibitor side chains with enzyme over a previous inhibitor, OM99-2 [Ghosh, A. K., et al. (2000) J. Am. Chem. Soc. 14, 3522-3523]....
A molecular model of OM00-3 binding to memapsin 2 revealed critical improvement of the interactions between inhibitor side chains with enzym …
15 results