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Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.
Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Kardon AP, et al. Neuron. 2014 May 7;82(3):573-86. doi: 10.1016/j.neuron.2014.02.046. Epub 2014 Apr 10. Neuron. 2014. PMID: 24726382 Free PMC article.
Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
Ganley RP, Iwagaki N, del Rio P, Baseer N, Dickie AC, Boyle KA, Polgár E, Watanabe M, Abraira VE, Zimmerman A, Riddell JS, Todd AJ. Ganley RP, et al. J Neurosci. 2015 May 13;35(19):7626-42. doi: 10.1523/JNEUROSCI.0406-15.2015. J Neurosci. 2015. PMID: 25972186 Free PMC article.