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298 results

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Page 1
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E. Kasinath V, et al. Science. 2021 Jan 22;371(6527):eabc3393. doi: 10.1126/science.abc3393. Science. 2021. PMID: 33479123 Free PMC article.
Our PRC2 cryo-electron microscopy structure with cofactors JARID2 and AEBP2 bound to a H2AK119ub1-containing nucleosome reveals a bridge helix in EZH2 that connects the SET domain, H3 tail, and nucleosomal DNA. JARID2 and AEBP2 each interact with one ubiquitin and t …
Our PRC2 cryo-electron microscopy structure with cofactors JARID2 and AEBP2 bound to a H2AK119ub1-containing nucleosome reveals a bri …
JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte-derived leptin.
Liu W, Zeng Y, Hao X, Wang X, Liu J, Gao T, Wang M, Zhang J, Huo M, Hu T, Ma T, Zhang D, Teng X, Yu H, Zhang M, Yuan B, Huang W, Yang Y, Wang Y. Liu W, et al. Cancer Commun (Lond). 2023 Oct;43(10):1117-1142. doi: 10.1002/cac2.12479. Epub 2023 Sep 1. Cancer Commun (Lond). 2023. PMID: 37658635 Free PMC article.
Spheroidization-based experiments and xenotumor transplantation in NOD/SCID mice were used to examine the association between JARID2 and breast cancer stemness. RNA-sequencing, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis were used to identify …
Spheroidization-based experiments and xenotumor transplantation in NOD/SCID mice were used to examine the association between JARID2 …
JARID2 and EZH2, the eminent epigenetic drivers in human cancer.
Sreeshma B, Devi A. Sreeshma B, et al. Gene. 2023 Aug 30;879:147584. doi: 10.1016/j.gene.2023.147584. Epub 2023 Jun 21. Gene. 2023. PMID: 37353042 Review.
In addition, EZH2 has detrimental effects leading to the onset and metastasis of several cancers. Jumonji AT Rich Interacting Domain2 (JARID2), an undebated crucial nuclear factor, has strong coordination with the PRC2 family. In this review, we discuss various epigenetic …
In addition, EZH2 has detrimental effects leading to the onset and metastasis of several cancers. Jumonji AT Rich Interacting Domain2 (JA …
Autoregulation of JARID2 through PRC2 interaction with its antisense ncRNA.
Al-Raawi D, Kanhere A. Al-Raawi D, et al. BMC Res Notes. 2020 Oct 30;13(1):501. doi: 10.1186/s13104-020-05348-z. BMC Res Notes. 2020. PMID: 33126912 Free PMC article.
JARID2 along with PRC2 is indispensable for normal development. However, it remains unclear how JARID2 expression itself is regulated. ...The objective of this study was to explore the role of JARID2-AS1 in regulating JARID2 and consequently PRC2. RESU …
JARID2 along with PRC2 is indispensable for normal development. However, it remains unclear how JARID2 expression itself is re …
DNA Methylation Signature for JARID2-Neurodevelopmental Syndrome.
Verberne EA, van der Laan L, Haghshenas S, Rooney K, Levy MA, Alders M, Maas SM, Jansen S, Lieden A, Anderlid BM, Rafael-Croes L, Campeau PM, Chaudhry A, Koolen DA, Pfundt R, Hurst ACE, Tran-Mau-Them F, Bruel AL, Lambert L, Isidor B, Mannens MMAM, Sadikovic B, Henneman P, van Haelst MM. Verberne EA, et al. Int J Mol Sci. 2022 Jul 20;23(14):8001. doi: 10.3390/ijms23148001. Int J Mol Sci. 2022. PMID: 35887345 Free PMC article.
JARID2 encodes a transcriptional repressor protein that regulates the activity of various histone methyltransferase complexes. ...In this study we aim to detect a specific and sensitive DNA methylation signature for JARID2-neurodevelopmental syndrome. Peripheral blo …
JARID2 encodes a transcriptional repressor protein that regulates the activity of various histone methyltransferase complexes. ...In …
Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
Zhang J, Roberts JM, Chang F, Schwakopf J, Vetter ML. Zhang J, et al. Cell Rep. 2023 Mar 28;42(3):112237. doi: 10.1016/j.celrep.2023.112237. Epub 2023 Mar 14. Cell Rep. 2023. PMID: 36924502 Free PMC article.
We find that the transition from early to late progenitor competence is regulated by Jarid2. Loss of Jarid2 results in extended production of early cell types and extended expression of early progenitor genes. Jarid2 can regulate histone modifications, and we …
We find that the transition from early to late progenitor competence is regulated by Jarid2. Loss of Jarid2 results in extende …
JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome.
Verberne EA, Goh S, England J, van Ginkel M, Rafael-Croes L, Maas S, Polstra A, Zarate YA, Bosanko KA, Pechter KB, Bedoukian E, Izumi K, Chaudhry A, Robin NH, Boothe M, Lippa NC, Aggarwal V, De Vivo DC, Lehman A, Study C, Stockler S, Bruel AL, Isidor B, Lemons J, Rodriguez-Buritica DF, Richmond CM, Stark Z, Agrawal PB, Kooy RF, Meuwissen MEC, Koolen DA, Pfundt R, Lieden A, Anderlid BM, Glatz D, Mannens MMAM, Bakshi M, Mallette FA, van Haelst MM, Campeau PM. Verberne EA, et al. Genet Med. 2021 Feb;23(2):374-383. doi: 10.1038/s41436-020-00992-z. Epub 2020 Oct 20. Genet Med. 2021. PMID: 33077894 Free article.
PURPOSE: JARID2, located on chromosome 6p22.3, is a regulator of histone methyltransferase complexes that is expressed in human neurons. ...We aim to confirm JARID2 as a human disease gene and further elucidate the associated clinical phenotype. ...
PURPOSE: JARID2, located on chromosome 6p22.3, is a regulator of histone methyltransferase complexes that is expressed in human neuro …
JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis.
Gu Y, Ding Z, Zhou Q, Li J, Qian W. Gu Y, et al. Reprod Biol. 2023 Mar;23(1):100729. doi: 10.1016/j.repbio.2023.100729. Epub 2023 Jan 12. Reprod Biol. 2023. PMID: 36640627
However, whether JARID2 has the same function in EMs is not yet known. In this study, A retrospective immunohistochemistry(IHC) was used to measure the expression of JARID2, E-cadherin, PTEN, and p-AKT in ovarian endometriosis (OE) tissues. ...Accordingly, the oppos …
However, whether JARID2 has the same function in EMs is not yet known. In this study, A retrospective immunohistochemistry(IHC) was u …
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1.
Wang Q, Wu J, Wei H, Huang H, Huang Y, Fang H, Gong X, Sun J, Wu Y, Lei C, Yu J, Hu D. Wang Q, et al. Int J Biochem Cell Biol. 2021 Sep;138:106040. doi: 10.1016/j.biocel.2021.106040. Epub 2021 Jul 8. Int J Biochem Cell Biol. 2021. PMID: 34246759
The function of JARID2 in modulating CDDP sensitivity of NSCLC cells was determined. It was found that JARID2 is upregulated in CDDP resistant NSCLC cells, which depends on SOX2 expression. JARID2 overexpression promotes CDDP resistance in NSCLC cells, wherea …
The function of JARID2 in modulating CDDP sensitivity of NSCLC cells was determined. It was found that JARID2 is upregulated i …
Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling.
Wang X, Lyu J, Ji A, Zhang Q, Liao G. Wang X, et al. Life Sci. 2019 Aug 1;230:162-168. doi: 10.1016/j.lfs.2019.05.053. Epub 2019 May 21. Life Sci. 2019. PMID: 31125562
In the present study, we aimed to explore whether Jarid2 could interact with H3K27me3 to regulate PTEN expression in bladder cancer. MAIN METHODS: Jarid2 expression in bladder cancer tissues and cells were determined by western blotting and RT-PCR. ...Jarid2 …
In the present study, we aimed to explore whether Jarid2 could interact with H3K27me3 to regulate PTEN expression in bladder cancer. …
298 results