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320 results

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Page 1
JARID2 and EZH2, the eminent epigenetic drivers in human cancer.
Sreeshma B, Devi A. Sreeshma B, et al. Gene. 2023 Aug 30;879:147584. doi: 10.1016/j.gene.2023.147584. Epub 2023 Jun 21. Gene. 2023. PMID: 37353042 Review.
In addition, EZH2 has detrimental effects leading to the onset and metastasis of several cancers. Jumonji AT Rich Interacting Domain2 (JARID2), an undebated crucial nuclear factor, has strong coordination with the PRC2 family. In this review, we discuss various epigenetic …
In addition, EZH2 has detrimental effects leading to the onset and metastasis of several cancers. Jumonji AT Rich Interacting Domain2 (JA …
JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte-derived leptin.
Liu W, Zeng Y, Hao X, Wang X, Liu J, Gao T, Wang M, Zhang J, Huo M, Hu T, Ma T, Zhang D, Teng X, Yu H, Zhang M, Yuan B, Huang W, Yang Y, Wang Y. Liu W, et al. Cancer Commun (Lond). 2023 Oct;43(10):1117-1142. doi: 10.1002/cac2.12479. Epub 2023 Sep 1. Cancer Commun (Lond). 2023. PMID: 37658635 Free PMC article.
Spheroidization-based experiments and xenotumor transplantation in NOD/SCID mice were used to examine the association between JARID2 and breast cancer stemness. RNA-sequencing, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis were used to identify …
Spheroidization-based experiments and xenotumor transplantation in NOD/SCID mice were used to examine the association between JARID2 …
Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
Zhang J, Roberts JM, Chang F, Schwakopf J, Vetter ML. Zhang J, et al. Cell Rep. 2023 Mar 28;42(3):112237. doi: 10.1016/j.celrep.2023.112237. Epub 2023 Mar 14. Cell Rep. 2023. PMID: 36924502 Free PMC article.
We find that the transition from early to late progenitor competence is regulated by Jarid2. Loss of Jarid2 results in extended production of early cell types and extended expression of early progenitor genes. Jarid2 can regulate histone modifications, and we …
We find that the transition from early to late progenitor competence is regulated by Jarid2. Loss of Jarid2 results in extende …
DNA Methylation Signature for JARID2-Neurodevelopmental Syndrome.
Verberne EA, van der Laan L, Haghshenas S, Rooney K, Levy MA, Alders M, Maas SM, Jansen S, Lieden A, Anderlid BM, Rafael-Croes L, Campeau PM, Chaudhry A, Koolen DA, Pfundt R, Hurst ACE, Tran-Mau-Them F, Bruel AL, Lambert L, Isidor B, Mannens MMAM, Sadikovic B, Henneman P, van Haelst MM. Verberne EA, et al. Int J Mol Sci. 2022 Jul 20;23(14):8001. doi: 10.3390/ijms23148001. Int J Mol Sci. 2022. PMID: 35887345 Free PMC article.
JARID2 encodes a transcriptional repressor protein that regulates the activity of various histone methyltransferase complexes. ...In this study we aim to detect a specific and sensitive DNA methylation signature for JARID2-neurodevelopmental syndrome. Peripheral blo …
JARID2 encodes a transcriptional repressor protein that regulates the activity of various histone methyltransferase complexes. ...In …
JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome.
Verberne EA, Goh S, England J, van Ginkel M, Rafael-Croes L, Maas S, Polstra A, Zarate YA, Bosanko KA, Pechter KB, Bedoukian E, Izumi K, Chaudhry A, Robin NH, Boothe M, Lippa NC, Aggarwal V, De Vivo DC, Lehman A, Study C, Stockler S, Bruel AL, Isidor B, Lemons J, Rodriguez-Buritica DF, Richmond CM, Stark Z, Agrawal PB, Kooy RF, Meuwissen MEC, Koolen DA, Pfundt R, Lieden A, Anderlid BM, Glatz D, Mannens MMAM, Bakshi M, Mallette FA, van Haelst MM, Campeau PM. Verberne EA, et al. Genet Med. 2021 Feb;23(2):374-383. doi: 10.1038/s41436-020-00992-z. Epub 2020 Oct 20. Genet Med. 2021. PMID: 33077894 Free article.
PURPOSE: JARID2, located on chromosome 6p22.3, is a regulator of histone methyltransferase complexes that is expressed in human neurons. ...We aim to confirm JARID2 as a human disease gene and further elucidate the associated clinical phenotype. ...
PURPOSE: JARID2, located on chromosome 6p22.3, is a regulator of histone methyltransferase complexes that is expressed in human neuro …
JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis.
Gu Y, Ding Z, Zhou Q, Li J, Qian W. Gu Y, et al. Reprod Biol. 2023 Mar;23(1):100729. doi: 10.1016/j.repbio.2023.100729. Epub 2023 Jan 12. Reprod Biol. 2023. PMID: 36640627
However, whether JARID2 has the same function in EMs is not yet known. In this study, A retrospective immunohistochemistry(IHC) was used to measure the expression of JARID2, E-cadherin, PTEN, and p-AKT in ovarian endometriosis (OE) tissues. ...Accordingly, the oppos …
However, whether JARID2 has the same function in EMs is not yet known. In this study, A retrospective immunohistochemistry(IHC) was u …
JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle.
Adhikari A, Mainali P, Davie JK. Adhikari A, et al. J Biol Chem. 2019 Dec 20;294(51):19451-19464. doi: 10.1074/jbc.RA119.010060. Epub 2019 Oct 2. J Biol Chem. 2019. PMID: 31578284 Free PMC article.
JARID2 is a noncatalytic member of the polycomb repressive complex 2 (PRC2) which methylates of histone 3 lysine 27 (H3K27). ...Intriguingly, we also find that the retinoblastoma protein (RB1) is a direct target of JARID2 and the PRC2 complex. The depletion of JA …
JARID2 is a noncatalytic member of the polycomb repressive complex 2 (PRC2) which methylates of histone 3 lysine 27 (H3K27). ...Intri …
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1.
Wang Q, Wu J, Wei H, Huang H, Huang Y, Fang H, Gong X, Sun J, Wu Y, Lei C, Yu J, Hu D. Wang Q, et al. Int J Biochem Cell Biol. 2021 Sep;138:106040. doi: 10.1016/j.biocel.2021.106040. Epub 2021 Jul 8. Int J Biochem Cell Biol. 2021. PMID: 34246759
The function of JARID2 in modulating CDDP sensitivity of NSCLC cells was determined. It was found that JARID2 is upregulated in CDDP resistant NSCLC cells, which depends on SOX2 expression. JARID2 overexpression promotes CDDP resistance in NSCLC cells, wherea …
The function of JARID2 in modulating CDDP sensitivity of NSCLC cells was determined. It was found that JARID2 is upregulated i …
Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling.
Wang X, Lyu J, Ji A, Zhang Q, Liao G. Wang X, et al. Life Sci. 2019 Aug 1;230:162-168. doi: 10.1016/j.lfs.2019.05.053. Epub 2019 May 21. Life Sci. 2019. PMID: 31125562
In the present study, we aimed to explore whether Jarid2 could interact with H3K27me3 to regulate PTEN expression in bladder cancer. MAIN METHODS: Jarid2 expression in bladder cancer tissues and cells were determined by western blotting and RT-PCR. ...Jarid2 …
In the present study, we aimed to explore whether Jarid2 could interact with H3K27me3 to regulate PTEN expression in bladder cancer. …
JARID2 activation by NFYA promotes stemness of triple-negative breast cancer cells through the PI3K/AKT pathway.
Li J, Zhang X, Liu X, Ma X, Wang Y, Liu Y. Li J, et al. Expert Rev Anticancer Ther. 2024 Oct;24(10):1029-1040. doi: 10.1080/14737140.2024.2394167. Epub 2024 Sep 10. Expert Rev Anticancer Ther. 2024. PMID: 39254227
A xenograft tumor model verified the effect of JARID2 in vivo. RESULTS: JARID2 and nuclear transcription factor Y subunit alpha (NFYA) were upregulated in TNBC tissues and positively correlated. ...CONCLUSIONS: NFYA promotes TNBC cell stemness by upregulating JAR …
A xenograft tumor model verified the effect of JARID2 in vivo. RESULTS: JARID2 and nuclear transcription factor Y subunit alph …
320 results