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The JCSG high-throughput structural biology pipeline.
Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wooley J, Wüthrich K, Wilson IA. Elsliger MA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1137-42. doi: 10.1107/S1744309110038212. Epub 2010 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20944202 Free PMC article.
The Joint Center for Structural Genomics high-throughput structural biology pipeline has delivered more than 1000 structures to the community over the past ten years. The JCSG has made a significant contribution to the overall goal of the NIH Protein Structure Initiative ( …
The Joint Center for Structural Genomics high-throughput structural biology pipeline has delivered more than 1000 structures to the communit …
Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy.
Newman J, Egan D, Walter TS, Meged R, Berry I, Ben Jelloul M, Sussman JL, Stuart DI, Perrakis A. Newman J, et al. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1426-31. doi: 10.1107/S0907444905024984. Epub 2005 Sep 28. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16204897
The sparse-matrix screen is the cherry-picked combination of conditions from the Joint Center for Structural Genomics (JCSG) extended using conditions from other screens. Its aim is to maximize the coverage of crystallization parameter space with no redundancy. ...
The sparse-matrix screen is the cherry-picked combination of conditions from the Joint Center for Structural Genomics (JCSG) extended …
TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures.
Krishna SS, Weekes D, Bakolitsa C, Elsliger MA, Wilson IA, Godzik A, Wooley J. Krishna SS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1143-7. doi: 10.1107/S1744309110035736. Epub 2010 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20944203 Free PMC article.
The NIH Protein Structure Initiative centers, such as the Joint Center for Structural Genomics (JCSG), have developed highly efficient technological platforms that are capable of experimentally determining the three-dimensional structures of hundreds of proteins per year. …
The NIH Protein Structure Initiative centers, such as the Joint Center for Structural Genomics (JCSG), have developed highly efficien …
NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia.
Serrano P, Dutta SK, Proudfoot A, Mohanty B, Susac L, Martin B, Geralt M, Jaroszewski L, Godzik A, Elsliger M, Wilson IA, Wüthrich K. Serrano P, et al. FEBS J. 2016 Nov;283(21):3870-3881. doi: 10.1111/febs.13751. Epub 2016 Jun 9. FEBS J. 2016. PMID: 27154589 Free PMC article.
For more than a decade, the Joint Center for Structural Genomics (JCSG; www.jcsg.org) worked toward increased three-dimensional structure coverage of the protein universe. ...Here, we describe what could be achieved by this structural genomics approach, using as an …
For more than a decade, the Joint Center for Structural Genomics (JCSG; www.jcsg.org) worked toward increased three-dimensiona …
The JCSG MR pipeline: optimized alignments, multiple models and parallel searches.
Schwarzenbacher R, Godzik A, Jaroszewski L. Schwarzenbacher R, et al. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. doi: 10.1107/S0907444907050111. Epub 2007 Dec 5. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18094477 Free PMC article.
In addition, by designing MR pipelines that integrate phasing and automated refinement and allow parallel processing of such calculations, one can effectively increase the success rate of MR. Here, updated results from the JCSG MR pipeline are presented, which to date has …
In addition, by designing MR pipelines that integrate phasing and automated refinement and allow parallel processing of such calculations, o …
Distributed structure determination at the JCSG.
van den Bedem H, Wolf G, Xu Q, Deacon AM. van den Bedem H, et al. Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):368-75. doi: 10.1107/S0907444910039934. Epub 2011 Mar 18. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21460455 Free PMC article.
The Joint Center for Structural Genomics (JCSG), one of four large-scale structure-determination centers funded by the US Protein Structure Initiative (PSI) through the National Institute for General Medical Sciences, has been operating an automated distributed structure-s …
The Joint Center for Structural Genomics (JCSG), one of four large-scale structure-determination centers funded by the US Protein Str …
Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites.
Serrano P, Pedrini B, Geralt M, Jaudzems K, Mohanty B, Horst R, Herrmann T, Elsliger MA, Wilson IA, Wüthrich K. Serrano P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1393-405. doi: 10.1107/S1744309110033658. Epub 2010 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20944236 Free PMC article.
The JCSG has recently developed a protocol for systematic comparisons of high-quality crystal and NMR structures of proteins. ...The corresponding crystal structures were solved by the JCSG at 100 K and 1.6 A resolution and at 100 K and 1.9 A resolution, respectivel …
The JCSG has recently developed a protocol for systematic comparisons of high-quality crystal and NMR structures of proteins. ...The …
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