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RhoA and ERK signalling regulate the expression of the transcription factor Nfix in myogenic cells.
Taglietti V, Angelini G, Mura G, Bonfanti C, Caruso E, Monteverde S, Le Carrou G, Tajbakhsh S, Relaix F, Messina G. Taglietti V, et al. Development. 2018 Oct 29;145(21):dev163956. doi: 10.1242/dev.163956. Development. 2018. PMID: 30266829 Free article.
The transcription factor Nfix belongs to the nuclear factor one family and has an essential role in prenatal skeletal muscle development, where it is a master regulator of the transition from embryonic to foetal myogenesis. ...Specifically, RhoA and ROCK repress ERK …
The transcription factor Nfix belongs to the nuclear factor one family and has an essential role in prenatal skeletal muscle d …
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis.
Braun T, Gautel M. Braun T, et al. Nat Rev Mol Cell Biol. 2011 Jun;12(6):349-61. doi: 10.1038/nrm3118. Nat Rev Mol Cell Biol. 2011. PMID: 21602905 Review.
Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic …
Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts lar …
A requirement for fibroblast growth factor in regulation of skeletal muscle growth and differentiation cannot be replaced by activation of platelet-derived growth factor signaling pathways.
Kudla AJ, John ML, Bowen-Pope DF, Rainish B, Olwin BB. Kudla AJ, et al. Mol Cell Biol. 1995 Jun;15(6):3238-46. doi: 10.1128/mcb.15.6.3238. Mol Cell Biol. 1995. PMID: 7760819 Free PMC article.
In contrast to PDGF-BB, addition of FGF-2 to myoblasts activated signaling pathways that resulted in DNA synthesis and repression of differentiation. ...As the PDGF beta receptor- and FGF receptor-stimulated signaling pathways yield different biological responses in these …
In contrast to PDGF-BB, addition of FGF-2 to myoblasts activated signaling pathways that resulted in DNA synthesis and repression of …
GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.
Wang D, Bai X, Tian Q, Lai Y, Lin EA, Shi Y, Mu X, Feng JQ, Carlson CS, Liu CJ. Wang D, et al. Cell Mol Life Sci. 2012 Jun;69(11):1855-73. doi: 10.1007/s00018-011-0901-5. Epub 2011 Dec 17. Cell Mol Life Sci. 2012. PMID: 22179841 Free PMC article.
Here we report that GEP was expressed in skeletal muscle tissue and its level was differentially altered in the course of C2C12 myoblast fusion. ...Mechanistic studies revealed that during myoblast fusion, the addition of GEP led to remarkable reductio …
Here we report that GEP was expressed in skeletal muscle tissue and its level was differentially altered in the course of C2C1 …
LIF is a contraction-induced myokine stimulating human myocyte proliferation.
Broholm C, Laye MJ, Brandt C, Vadalasetty R, Pilegaard H, Pedersen BK, Scheele C. Broholm C, et al. J Appl Physiol (1985). 2011 Jul;111(1):251-9. doi: 10.1152/japplphysiol.01399.2010. Epub 2011 Apr 28. J Appl Physiol (1985). 2011. PMID: 21527666 Free article.
The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of human muscle …
The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. W …
Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes.
Broholm C, Brandt C, Schultz NS, Nielsen AR, Pedersen BK, Scheele C. Broholm C, et al. Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E283-92. doi: 10.1152/ajpendo.00586.2011. Epub 2012 May 29. Am J Physiol Endocrinol Metab. 2012. PMID: 22649064 Free article.
The cytokine leukemia-inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of muscle precursor cells, an important feature of skeletal muscle maintenance and repair. ...Myoblast proliferation rate was assessed …
The cytokine leukemia-inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of muscle precu …
SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.
Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T. Ouyang X, et al. J Cell Physiol. 2006 May;207(2):428-36. doi: 10.1002/jcp.20579. J Cell Physiol. 2006. PMID: 16419040
Suppressor of cytokine signaling (SOCS)-2 regulates normal postnatal growth and its deficiency in mice causes gigantism with increased bone length and proportional enlargement in skeletal muscles. ...In addition, the proteasome inhibitor enhanced JunB protein expres …
Suppressor of cytokine signaling (SOCS)-2 regulates normal postnatal growth and its deficiency in mice causes gigantism with increased bone …
JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2.
Chalaux E, López-Rovira T, Rosa JL, Bartrons R, Ventura F. Chalaux E, et al. J Biol Chem. 1998 Jan 2;273(1):537-43. doi: 10.1074/jbc.273.1.537. J Biol Chem. 1998. PMID: 9417113 Free article.
BMPs were first identified by their osteoinductive effects, inducing ectopic bone formation when implanted in skeletal muscle, and have an important role as regulators of skeletal development in vivo. ...Increase of JunB mRNA correlates with a higher A …
BMPs were first identified by their osteoinductive effects, inducing ectopic bone formation when implanted in skeletal muscle, …
Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor beta.
Heino J, Massagué J. Heino J, et al. J Biol Chem. 1990 Jun 25;265(18):10181-4. J Biol Chem. 1990. PMID: 2162338 Free article.
Transforming growth factor beta 1 (TGF-beta 1) is an inhibitor of skeletal muscle myoblast differentiation. Myoblast differentiation is dependent on the expression of certain myogenic differentiation genes and is affected by cell interaction with the e …
Transforming growth factor beta 1 (TGF-beta 1) is an inhibitor of skeletal muscle myoblast differentiation. Myoblast …
Expression of the protooncogene c-jun is maintained during myogenic differentiation in rat L6 myoblasts.
Thinakaran G, Bag J. Thinakaran G, et al. Biochem Cell Biol. 1993 May-Jun;71(5-6):260-9. doi: 10.1139/o93-040. Biochem Cell Biol. 1993. PMID: 8274267
Skeletal myoblasts undergo terminal differentiation when maintained under low-mitogen conditions. We have examined the expression of c-jun, one of the growth-factor-inducible immediate-early genes, during myogenic differentiation of L6 myoblasts. ...Although …
Skeletal myoblasts undergo terminal differentiation when maintained under low-mitogen conditions. We have examined the express …
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