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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 1
2002 1
2003 5
2004 4
2005 7
2006 3
2007 13
2008 14
2009 13
2010 12
2011 16
2012 20
2013 19
2014 20
2015 20
2016 24
2017 19
2018 14
2019 26
2020 26
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2022 14
2023 13
2024 4

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269 results

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Page 1
The Impact of JWH-133 on Articular Cartilage Regeneration in Osteoarthritis Via Metalloproteinase 13-Dependent Mechanism.
Malek N, Borowczyk J, Kostrzewa M, Pawlowska A, Drukala J, Starowicz K. Malek N, et al. Cannabis Cannabinoid Res. 2023 Oct;8(5):779-789. doi: 10.1089/can.2022.0107. Epub 2022 Nov 1. Cannabis Cannabinoid Res. 2023. PMID: 36318796
Primary human chondrocytes treated with MIA were used to investigate action of JWH-133 on chondrocytes viability, proliferation, and motility. ...JWH-133 administration partially reduced toxicity, increased proliferation, and chondrocytes' migration. . …
Primary human chondrocytes treated with MIA were used to investigate action of JWH-133 on chondrocytes viability, proliferatio …
CB2R agonist JWH-133 attenuates chronic inflammation by restraining M1 macrophage polarization via Nrf2/HO-1 pathway in diet-induced obese mice.
Wu Q, Ma Y, Liu Y, Wang N, Zhao X, Wen D. Wu Q, et al. Life Sci. 2020 Nov 1;260:118424. doi: 10.1016/j.lfs.2020.118424. Epub 2020 Sep 17. Life Sci. 2020. PMID: 32949586
Furthermore, the underlying mechanisms were studied in an LPS-treated RAW264.7 cell line. We found a role for JWH-133 in controlling M1 macrophage polarization by activating the Nrf2/HO-1 pathway, while the effect of JWH-133 was diminished by a HO-1 in …
Furthermore, the underlying mechanisms were studied in an LPS-treated RAW264.7 cell line. We found a role for JWH-133 in contr …
Activation of cannabinoid 2 receptors by JWH-133 protects against ovarian ischemia-reperfusion injury in rats.
Onat T, Demir Caltekin M, Doğanyigit Z, Turkler C, Kaymak E, Kara M, Serdar Yalvac E. Onat T, et al. Biotech Histochem. 2021 Jul;96(5):394-400. doi: 10.1080/10520295.2021.1905183. Epub 2021 Apr 12. Biotech Histochem. 2021. PMID: 33840323
Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH-133 (JIRG1), ischemia-reperfusion + 1 mg/kg JWH-133 (JIRG2); ischemia-reperfusion + 5 mg/kg JWH-133 (JIRG3); …
Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH- …
Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Jiang F, Xia M, Zhang Y, Chang J, Cao J, Zhang Z, Qian Z, Yang L. Jiang F, et al. Front Immunol. 2022 Sep 26;13:993168. doi: 10.3389/fimmu.2022.993168. eCollection 2022. Front Immunol. 2022. PMID: 36238284 Free PMC article.
CB2R activation also increased ubiquitination of the NLRP3 inflammasome and interacted with the autophagy-related proteins p62 and microtubule-associated proteins 1B light chain 3. Treatment with the CB2R activator JWH-133 reduced loss of myelin, apoptosis of neuron …
CB2R activation also increased ubiquitination of the NLRP3 inflammasome and interacted with the autophagy-related proteins p62 and microtubu …
Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages.
Rosario-Rodríguez LJ, Gerena Y, García-Requena LA, Cartagena-Isern LJ, Cuadrado-Ruiz JC, Borges-Vélez G, Meléndez LM. Rosario-Rodríguez LJ, et al. Sci Rep. 2022 Jan 7;12(1):233. doi: 10.1038/s41598-021-03896-3. Sci Rep. 2022. PMID: 34996989 Free PMC article.
Primary MDM were inoculated with HIV-1(ADA) and treated with selective CB2R agonists JWH-133 and HU-308. HIV-1 p24 and CATB levels were determined from supernatants using ELISA. MDM were pre-treated with a selective CB2R antagonist SR144528 before JWH-133
Primary MDM were inoculated with HIV-1(ADA) and treated with selective CB2R agonists JWH-133 and HU-308. HIV-1 p24 and CATB le …
The Activation of Cannabinoid Type-2 Receptor with JWH-133 Protects Uterine Ischemia/Reperfusion-Induced Damage.
Aydogan Kirmizi D, Baser E, Doganyigit Z. Aydogan Kirmizi D, et al. Pharmacology. 2021;106(1-2):106-113. doi: 10.1159/000511457. Epub 2020 Oct 26. Pharmacology. 2021. PMID: 33105141
This study provides information on the potential applications cannabinoids agonist JWH-133 in uterine IR damage and, hence, in the transplant process. METHODS: Rats were divided into 4 groups (n = 8), performed uterine IR, and treated 2 groups with JWH-133
This study provides information on the potential applications cannabinoids agonist JWH-133 in uterine IR damage and, hence, in …
Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats.
Çakır M, Tekin S, Doğanyiğit Z, Erden Y, Soytürk M, Çiğremiş Y, Sandal S. Çakır M, et al. Life Sci. 2019 Jan 15;217:25-33. doi: 10.1016/j.lfs.2018.11.058. Epub 2018 Nov 28. Life Sci. 2019. PMID: 30500552
MATERIALS AND METHODS: In this study, 40 Sprague Dawley male rats were divided into 4 groups (Control, Sham, OKA, OKA + JWH-133). Bilateral intracerebroventricular (icv) injection of 200 ng OKA was performed in the OKA group. In the OKA + JWH-133 group …
MATERIALS AND METHODS: In this study, 40 Sprague Dawley male rats were divided into 4 groups (Control, Sham, OKA, OKA + JWH-133
Chronic Administration of Cannabinoid Receptor 2 Agonist (JWH-133) Increases Ectopic Ovarian Tumor Growth and Endocannabinoids (Anandamide and 2-Arachidonoyl Glycerol) Levels in Immunocompromised SCID Female Mice.
Blanton HL, McHann MC, De Selle H, Dancel CL, Redondo JL, Molehin D, German NA, Trasti S, Pruitt K, Castro-Piedras I, Guindon J. Blanton HL, et al. Front Pharmacol. 2022 Feb 15;13:823132. doi: 10.3389/fphar.2022.823132. eCollection 2022. Front Pharmacol. 2022. PMID: 35242036 Free PMC article.
Recently, cannabinoids have gained increased attention for their effects on cancer growth. Indeed, the effect of CB(2) (JWH-015, JWH-133) agonists on breast cancer models have shown to reduce the size of breast cancer tumors. ...Our results demonstrate a significant …
Recently, cannabinoids have gained increased attention for their effects on cancer growth. Indeed, the effect of CB(2) (JWH-015, JWH- …
Unveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors?
Maia J, Fonseca BM, Teixeira N, Correia-da-Silva G. Maia J, et al. Biochem Pharmacol. 2023 Sep;215:115686. doi: 10.1016/j.bcp.2023.115686. Epub 2023 Jul 16. Biochem Pharmacol. 2023. PMID: 37463627 Free article. Review.
Here, we reviewed their impact on pro-angiogenic factors, extracellular matrix enzymes and inhibitors, immune-inflammatory responses, angiogenic pathways and functional assays, focusing on the main compounds for each cannabinoid class: THC and CBD for phytocannabinoids, anandamid …
Here, we reviewed their impact on pro-angiogenic factors, extracellular matrix enzymes and inhibitors, immune-inflammatory responses, angiog …
Eicosanoid mediation of cannabinoid actions.
Burstein SH. Burstein SH. Bioorg Med Chem. 2019 Jul 1;27(13):2718-2728. doi: 10.1016/j.bmc.2019.05.018. Epub 2019 May 13. Bioorg Med Chem. 2019. PMID: 31104784 Review.
The most widely studied cannabinoids so far are tetrahydrocannabinol and cannabidiol. However, synthetic agents such as CP55,940, ajulemic acid, JWH-133 and WIN-55,212-2 were also investigated for interaction with eicosanoids. ...
The most widely studied cannabinoids so far are tetrahydrocannabinol and cannabidiol. However, synthetic agents such as CP55,940, ajulemic a …
269 results