Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 1
2002 1
2003 5
2004 4
2005 7
2006 3
2007 13
2008 14
2009 13
2010 12
2011 16
2012 20
2013 19
2014 20
2015 20
2016 24
2017 19
2018 14
2019 26
2020 26
2021 17
2022 14
2023 13
2024 16
2025 14
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

297 results

Results by year

Filters applied: . Clear all
Page 1
The Impact of JWH-133 on Articular Cartilage Regeneration in Osteoarthritis Via Metalloproteinase 13-Dependent Mechanism.
Malek N, Borowczyk J, Kostrzewa M, Pawlowska A, Drukala J, Starowicz K. Malek N, et al. Cannabis Cannabinoid Res. 2023 Oct;8(5):779-789. doi: 10.1089/can.2022.0107. Epub 2022 Nov 1. Cannabis Cannabinoid Res. 2023. PMID: 36318796 Free PMC article.
We studied the action of dimethylbutyl-deoxy-delta-8-THC (JWH-133), selective CB2 agonist, on chondrocytes metabolism using both in vitro and in vivo studies. ...JWH-133 administration partially reduced toxicity, increased proliferation, and chondrocyt …
We studied the action of dimethylbutyl-deoxy-delta-8-THC (JWH-133), selective CB2 agonist, on chondrocytes metabolism using bo …
The Potential of JWH-133 to Inhibit the TLR4/NF-kappaB Signaling Pathway in Uterine Ischemia-Reperfusion Injury.
Inandiklioglu N, Onat T, Raheem KY, Kaya S. Inandiklioglu N, et al. Life (Basel). 2024 Sep 24;14(10):1214. doi: 10.3390/life14101214. Life (Basel). 2024. PMID: 39459513 Free PMC article.
Notably, in the 1 mg/kg JWH-133 group, all of the gene expression levels decreased significantly (p < 0.05). The molecular docking results showed that JWH-133 formed hydrogen bonds with GLU64 of IL-1beta, SER226 of IL-6, and SER62 of TNF-alpha. ...

Notably, in the 1 mg/kg JWH-133 group, all of the gene expression levels decreased significantly (p < 0.05). The molecular

…
CB2R agonist JWH-133 attenuates chronic inflammation by restraining M1 macrophage polarization via Nrf2/HO-1 pathway in diet-induced obese mice.
Wu Q, Ma Y, Liu Y, Wang N, Zhao X, Wen D. Wu Q, et al. Life Sci. 2020 Nov 1;260:118424. doi: 10.1016/j.lfs.2020.118424. Epub 2020 Sep 17. Life Sci. 2020. PMID: 32949586
We thus examined the anti-inflammatory activities of CB2R and a CB2R agonist, JWH-133, in diet-induced obese in mice as well as in cultured macrophages. MATERIALS AND METHODS: We evaluated the in vivo effect of JWH-133 on diet-induced adipose tissue in …
We thus examined the anti-inflammatory activities of CB2R and a CB2R agonist, JWH-133, in diet-induced obese in mice as well a …
Activation of cannabinoid 2 receptors by JWH-133 protects against ovarian ischemia-reperfusion injury in rats.
Onat T, Demir Caltekin M, Doğanyigit Z, Turkler C, Kaymak E, Kara M, Serdar Yalvac E. Onat T, et al. Biotech Histochem. 2021 Jul;96(5):394-400. doi: 10.1080/10520295.2021.1905183. Epub 2021 Apr 12. Biotech Histochem. 2021. PMID: 33840323
Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH-133 (JIRG1), ischemia-reperfusion + 1 mg/kg JWH-133 (JIRG2); ischemia-reperfusion + 5 mg/kg JWH-133 (JIRG3); …
Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH- …
Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages.
Rosario-Rodríguez LJ, Gerena Y, García-Requena LA, Cartagena-Isern LJ, Cuadrado-Ruiz JC, Borges-Vélez G, Meléndez LM. Rosario-Rodríguez LJ, et al. Sci Rep. 2022 Jan 7;12(1):233. doi: 10.1038/s41598-021-03896-3. Sci Rep. 2022. PMID: 34996989 Free PMC article.
Primary MDM were inoculated with HIV-1(ADA) and treated with selective CB2R agonists JWH-133 and HU-308. HIV-1 p24 and CATB levels were determined from supernatants using ELISA. MDM were pre-treated with a selective CB2R antagonist SR144528 before JWH-133 …
Primary MDM were inoculated with HIV-1(ADA) and treated with selective CB2R agonists JWH-133 and HU-308. HIV-1 p24 and CATB le …
JWH-133, a Selective Cannabinoid CB2 Receptor Agonist, Exerts Toxic Effects on Neuroblastoma SH-SY5Y Cells.
Wojcieszak J, Krzemień W, Zawilska JB. Wojcieszak J, et al. J Mol Neurosci. 2016 Apr;58(4):441-5. doi: 10.1007/s12031-016-0726-7. Epub 2016 Feb 3. J Mol Neurosci. 2016. PMID: 26842917
In addition, cell proliferation was measured using BrdU incorporation assay. JWH-133 (10-40 muM) induced a concentration-dependent decrease of SH-SY5Y cell viability and proliferation rate. Using AM-630, a reverse agonist of CB2 receptors, as well as Z-VAD-FMK, a pa …
In addition, cell proliferation was measured using BrdU incorporation assay. JWH-133 (10-40 muM) induced a concentration-depen …
Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats.
Çakır M, Tekin S, Doğanyiğit Z, Erden Y, Soytürk M, Çiğremiş Y, Sandal S. Çakır M, et al. Life Sci. 2019 Jan 15;217:25-33. doi: 10.1016/j.lfs.2018.11.058. Epub 2018 Nov 28. Life Sci. 2019. PMID: 30500552
We aimed to determine the possible effect of CB2 agonist JWH-133 in Okadaic acid (OKA)-induced neurodegeneration model mimicking Alzheimer's Disease (AD) through tau pathology. ...In the OKA + JWH-133 group, injection of JWH-133 (0.2 mg/k …
We aimed to determine the possible effect of CB2 agonist JWH-133 in Okadaic acid (OKA)-induced neurodegeneration model mimicki …
Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-kappaB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages.
Rosario-Rodríguez LJ, Cantres-Rosario YM, Carrasquillo-Carrión K, Rodríguez-De Jesús AE, Cartagena-Isern LJ, García-Requena LA, Roche-Lima A, Meléndez LM. Rosario-Rodríguez LJ, et al. Int J Mol Sci. 2024 Mar 13;25(6):3246. doi: 10.3390/ijms25063246. Int J Mol Sci. 2024. PMID: 38542221 Free PMC article.
While HIV-1 infection upregulated CATB, NF-kappaB signaling, Nrf2-mediated oxidative stress response, and lysosomal exocytosis, JWH-133 treatment downregulated the expression of the proteins involved in these pathways. Our results suggest that JWH-133 …
While HIV-1 infection upregulated CATB, NF-kappaB signaling, Nrf2-mediated oxidative stress response, and lysosomal exocytosis, JWH- …
Eicosanoid mediation of cannabinoid actions.
Burstein SH. Burstein SH. Bioorg Med Chem. 2019 Jul 1;27(13):2718-2728. doi: 10.1016/j.bmc.2019.05.018. Epub 2019 May 13. Bioorg Med Chem. 2019. PMID: 31104784 Review.
However, synthetic agents such as CP55,940, ajulemic acid, JWH-133 and WIN-55,212-2 were also investigated for interaction with eicosanoids. The endocannabinoids anandamide and 2-arachidonoylglycerol have been examined as well. ...
However, synthetic agents such as CP55,940, ajulemic acid, JWH-133 and WIN-55,212-2 were also investigated for interaction wit …
297 results