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The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design.
Jaakola VP, Ijzerman AP. Jaakola VP, et al. Curr Opin Struct Biol. 2010 Aug;20(4):401-14. doi: 10.1016/j.sbi.2010.05.002. Epub 2010 Jun 9. Curr Opin Struct Biol. 2010. PMID: 20538452 Review.
Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.
Katritch V, Jaakola VP, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Katritch V, et al. J Med Chem. 2010 Feb 25;53(4):1799-809. doi: 10.1021/jm901647p. J Med Chem. 2010. PMID: 20095623 Free PMC article.
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC. Jaakola VP, et al. Science. 2008 Nov 21;322(5905):1211-7. doi: 10.1126/science.1164772. Epub 2008 Oct 2. Science. 2008. PMID: 18832607 Free PMC article.
Structural features of adenosine receptors: from crystal to function.
Piirainen H, Ashok Y, Nanekar RT, Jaakola VP. Piirainen H, et al. Biochim Biophys Acta. 2011 May;1808(5):1233-44. doi: 10.1016/j.bbamem.2010.05.021. Epub 2010 Jun 2. Biochim Biophys Acta. 2011. PMID: 20595055 Review.
G protein-coupled receptors show unusual patterns of intrinsic unfolding.
Jaakola VP, Prilusky J, Sussman JL, Goldman A. Jaakola VP, et al. Protein Eng Des Sel. 2005 Feb;18(2):103-10. doi: 10.1093/protein/gzi004. Epub 2005 Mar 24. Protein Eng Des Sel. 2005. PMID: 15790574
Functional expression and direct visualization of the human alpha 2B -adrenergic receptor and alpha 2B -AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors.
Sen S, Jaakola VP, Heimo H, Engström M, Larjomaa P, Scheinin M, Lundstrom K, Goldman A. Sen S, et al. Protein Expr Purif. 2003 Dec;32(2):265-75. doi: 10.1016/j.pep.2003.08.006. Protein Expr Purif. 2003. PMID: 14965773
Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor.
Piirainen H, Taura J, Kursula P, Ciruela F, Jaakola VP. Piirainen H, et al. Among authors: jaakola vp. Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):674-686. doi: 10.1016/j.bbamcr.2017.01.013. Epub 2017 Jan 24. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28130124 Free article.
H(N), N, C(α), C(β) and C' assignments of the intrinsically disordered C-terminus of human adenosine A2A receptor.
Tossavainen H, Hellman M, Piirainen H, Jaakola VP, Permi P. Tossavainen H, et al. Biomol NMR Assign. 2015 Oct;9(2):403-6. doi: 10.1007/s12104-015-9618-y. Epub 2015 May 8. Biomol NMR Assign. 2015. PMID: 25952762
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