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Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim.
Periyasamy-Thandavan S, Takhar S, Singer A, Dohn MR, Jackson WH, Welborn AE, LeRoith D, Marrero M, Thangaraju M, Huang S, Schoenlein PV. Periyasamy-Thandavan S, et al. Among authors: jackson wh. Breast Cancer Res. 2012 Mar 19;14(2):R52. doi: 10.1186/bcr3153. Breast Cancer Res. 2012. PMID: 22429491 Free PMC article.
Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.
Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV. Periyasamy-Thandavan S, et al. Among authors: jackson wh. Autophagy. 2010 Jan;6(1):19-35. doi: 10.4161/auto.6.1.10323. Autophagy. 2010. PMID: 20110775
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