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DNA hypomethylation leads to elevated mutation rates.
Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R. Chen RZ, et al. Nature. 1998 Sep 3;395(6697):89-93. doi: 10.1038/25779. Nature. 1998. PMID: 9738504
DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A.
Ma Y, Jacobs SB, Jackson-Grusby L, Mastrangelo MA, Torres-Betancourt JA, Jaenisch R, Rasmussen TP. Ma Y, et al. J Cell Sci. 2005 Apr 15;118(Pt 8):1607-16. doi: 10.1242/jcs.02291. Epub 2005 Mar 22. J Cell Sci. 2005. PMID: 15784683
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Lin H, Yamada Y, Nguyen S, Linhart H, Jackson-Grusby L, Meissner A, Meletis K, Lo G, Jaenisch R. Lin H, et al. Among authors: jackson grusby l. Mol Cell Biol. 2006 Apr;26(8):2976-83. doi: 10.1128/MCB.26.8.2976-2983.2006. Mol Cell Biol. 2006. PMID: 16581773 Free PMC article.
Global loss of imprinting leads to widespread tumorigenesis in adult mice.
Holm TM, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout WM 3rd, Jaenisch R. Holm TM, et al. Among authors: jackson grusby l. Cancer Cell. 2005 Oct;8(4):275-85. doi: 10.1016/j.ccr.2005.09.007. Cancer Cell. 2005. PMID: 16226703 Free article.
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.
Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, Lin H, Jaenisch R. Yamada Y, et al. Among authors: jackson grusby l. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5. doi: 10.1073/pnas.0506612102. Epub 2005 Sep 8. Proc Natl Acad Sci U S A. 2005. PMID: 16174748 Free PMC article.
Induction of tumors in mice by genomic hypomethylation.
Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R. Gaudet F, et al. Science. 2003 Apr 18;300(5618):489-92. doi: 10.1126/science.1083558. Science. 2003. PMID: 12702876
Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.
Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R. Eggan K, et al. Nat Biotechnol. 2002 May;20(5):455-9. doi: 10.1038/nbt0502-455. Nat Biotechnol. 2002. PMID: 11981557
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation.
Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM 3rd, Yanagimachi R, Jaenisch R. Eggan K, et al. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6209-14. doi: 10.1073/pnas.101118898. Epub 2001 May 1. Proc Natl Acad Sci U S A. 2001. PMID: 11331774 Free PMC article.
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.
Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R. Jackson-Grusby L, et al. Nat Genet. 2001 Jan;27(1):31-9. doi: 10.1038/83730. Nat Genet. 2001. PMID: 11137995
Generation of mice from wild-type and targeted ES cells by nuclear cloning.
Rideout WM 3rd, Wakayama T, Wutz A, Eggan K, Jackson-Grusby L, Dausman J, Yanagimachi R, Jaenisch R. Rideout WM 3rd, et al. Nat Genet. 2000 Feb;24(2):109-10. doi: 10.1038/72753. Nat Genet. 2000. PMID: 10655052 No abstract available.
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