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Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG. Trifunovic A, et al. Among authors: jacobs ht. Nature. 2004 May 27;429(6990):417-23. doi: 10.1038/nature02517. Nature. 2004. PMID: 15164064
The dangers of extended PCR in the clinic.
Kajander OA, Poulton J, Spelbrink JN, Rovio A, Karhunen PJ, Jacobs HT. Kajander OA, et al. Among authors: jacobs ht. Nat Med. 1999 Sep;5(9):965-6. doi: 10.1038/12379. Nat Med. 1999. PMID: 10470052 No abstract available.
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, Santoro L, Toscano A, Fabrizi GM, Somer H, Croxen R, Beeson D, Poulton J, Suomalainen A, Jacobs HT, Zeviani M, Larsson C. Spelbrink JN, et al. Among authors: jacobs ht. Nat Genet. 2001 Jul;28(3):223-31. doi: 10.1038/90058. Nat Genet. 2001. PMID: 11431692
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.
Rovio AT, Marchington DR, Donat S, Schuppe HC, Abel J, Fritsche E, Elliott DJ, Laippala P, Ahola AL, McNay D, Harrison RF, Hughes B, Barrett T, Bailey DM, Mehmet D, Jequier AM, Hargreave TB, Kao SH, Cummins JM, Barton DE, Cooke HJ, Wei YH, Wichmann L, Poulton J, Jacobs HT. Rovio AT, et al. Among authors: jacobs ht. Nat Genet. 2001 Nov;29(3):261-2. doi: 10.1038/ng759. Nat Genet. 2001. PMID: 11687794
180 results