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Elimination of PknL and MSMEG_4242 in Mycobacterium smegmatis alters the character of the outer cell envelope and selects for mutations in Lsr2.
Báez-Ramírez E, Querales L, Aranaga CA, López G, Guerrero E, Kremer L, Carrère-Kremer S, Viljoen A, Daffé M, Laval F, Cole ST, Benjak A, Alzari P, André-Leroux G, Jacobs WR Jr, Vilcheze C, Takiff HE. Báez-Ramírez E, et al. Among authors: jacobs wr jr. Cell Surf. 2021 Aug 25;7:100060. doi: 10.1016/j.tcsw.2021.100060. eCollection 2021 Dec. Cell Surf. 2021. PMID: 34485766 Free PMC article.
A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.
Kaugars K, Dardick J, de Oliveira AP, Weiss KA, Lukose R, Kim J, Leung L, Rajagopalan S, Wolin S, Akabas L, Knipe DM, Bajic G, Jacobs WR Jr. Kaugars K, et al. Among authors: jacobs wr jr. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2110714118. doi: 10.1073/pnas.2110714118. Proc Natl Acad Sci U S A. 2021. PMID: 34417304
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
Gupta P, Thomas SE, Zaidan SA, Pasillas MA, Cory-Wright J, Sebastián-Pérez V, Burgess A, Cattermole E, Meghir C, Abell C, Coyne AG, Jacobs WR Jr, Blundell TL, Tiwari S, Mendes V. Gupta P, et al. Among authors: jacobs wr jr. Comput Struct Biotechnol J. 2021 Jun 4;19:3491-3506. doi: 10.1016/j.csbj.2021.06.006. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34194673 Free PMC article.
BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis.
Tiwari S, Dutt TS, Chen B, Chen M, Kim J, Dai AZ, Lukose R, Shanley C, Fox A, Karger BR, Porcelli SA, Chan J, Podell BK, Obregon-Henao A, Orme IM, Jacobs WR Jr, Henao-Tamayo M. Tiwari S, et al. Among authors: jacobs wr jr. Vaccine. 2020 Oct 21;38(45):7156-7165. doi: 10.1016/j.vaccine.2020.08.004. Epub 2020 Sep 23. Vaccine. 2020. PMID: 32978002 Free PMC article.
Nanoluciferase Reporter Mycobacteriophage for Sensitive and Rapid Detection of Mycobacterium tuberculosis Drug Susceptibility.
Jain P, Garing S, Verma D, Saranathan R, Clute-Reinig N, Gadwa J, Peterson C, Hermansky G, Astashkina Fernandez A, Asare E, Weisbrod TR, Spencer E, Mulholland CV, Berney M, Bell D, Nichols KP, Le Ny AM, Ordway D, Jacobs WR Jr, Somoskovi A, Minch KJ. Jain P, et al. Among authors: jacobs wr jr. J Bacteriol. 2020 Oct 22;202(22):e00411-20. doi: 10.1128/JB.00411-20. Print 2020 Oct 22. J Bacteriol. 2020. PMID: 32900827 Free PMC article.
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