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CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
Cummins CL, Jacobsen W, Christians U, Benet LZ. Cummins CL, et al. Among authors: jacobsen w. J Pharmacol Exp Ther. 2004 Jan;308(1):143-55. doi: 10.1124/jpet.103.058065. Epub 2003 Oct 20. J Pharmacol Exp Ther. 2004. PMID: 14569063
Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
Cummins CL, Jacobsen W, Benet LZ. Cummins CL, et al. Among authors: jacobsen w. J Pharmacol Exp Ther. 2002 Mar;300(3):1036-45. doi: 10.1124/jpet.300.3.1036. J Pharmacol Exp Ther. 2002. PMID: 11861813
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Frassetto L, et al. Among authors: jacobsen w. Transplantation. 2005 Jul 15;80(1):13-7. doi: 10.1097/01.tp.0000165111.09687.4e. Transplantation. 2005. PMID: 16003227
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Niemann CU, et al. Among authors: jacobsen w. J Pharmacol Exp Ther. 2002 Sep;302(3):1123-8. doi: 10.1124/jpet.102.036848. J Pharmacol Exp Ther. 2002. PMID: 12183671
Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.
Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Jacobsen W, et al. Transplant Proc. 2001 Feb-Mar;33(1-2):514-5. doi: 10.1016/s0041-1345(00)02116-3. Transplant Proc. 2001. PMID: 11266932 No abstract available.
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Serkova N, et al. Among authors: jacobsen w. Br J Pharmacol. 2001 Jul;133(6):875-85. doi: 10.1038/sj.bjp.0704142. Br J Pharmacol. 2001. PMID: 11454661 Free PMC article.
Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations.
Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Kuhn B, et al. Among authors: jacobsen w. J Med Chem. 2001 Jun 7;44(12):2027-34. doi: 10.1021/jm010079y. J Med Chem. 2001. PMID: 11384247
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Jacobsen W, et al. Drug Metab Dispos. 2000 Nov;28(11):1369-78. Drug Metab Dispos. 2000. PMID: 11038166
In vitro evaluation of the disposition of A novel cysteine protease inhibitor.
Jacobsen W, Christians U, Benet LZ. Jacobsen W, et al. Drug Metab Dispos. 2000 Nov;28(11):1343-51. Drug Metab Dispos. 2000. PMID: 11038163
Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Serkova N, et al. Among authors: jacobsen w. J Pharmacol Exp Ther. 2000 Jul;294(1):323-32. J Pharmacol Exp Ther. 2000. PMID: 10871329
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