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The end justifies the means.
Jacobson A. Jacobson A. Nat Struct Mol Biol. 2005 Jun;12(6):474-5. doi: 10.1038/nsmb0605-474. Nat Struct Mol Biol. 2005. PMID: 15933730 No abstract available.
NMD: a multifaceted response to premature translational termination.
Kervestin S, Jacobson A. Kervestin S, et al. Nat Rev Mol Cell Biol. 2012 Nov;13(11):700-12. doi: 10.1038/nrm3454. Epub 2012 Oct 17. Nat Rev Mol Cell Biol. 2012. PMID: 23072888 Free PMC article. Review.
In the nonsense-mediated decay (NMD) pathway premature translation termination promotes the recruitment of a set of factors that destabilize a targeted mRNA. ...
In the nonsense-mediated decay (NMD) pathway premature translation termination promotes the recruitment of a set of factors that dest …
Translation factors promote the formation of two states of the closed-loop mRNP.
Amrani N, Ghosh S, Mangus DA, Jacobson A. Amrani N, et al. Nature. 2008 Jun 26;453(7199):1276-80. doi: 10.1038/nature06974. Epub 2008 May 21. Nature. 2008. PMID: 18496529 Free PMC article.
The integrity of both forms requires the mRNA cap and poly(A) tail, as well as eIF4E, eIF4G, Pab1 and eIF3, and is dependent on the length of both the mRNA and the poly(A) tail. ...The involvement of the termination factors is independent of a termination eve …
The integrity of both forms requires the mRNA cap and poly(A) tail, as well as eIF4E, eIF4G, Pab1 and eIF3, and is dependent on the l …
A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay.
Amrani N, Ganesan R, Kervestin S, Mangus DA, Ghosh S, Jacobson A. Amrani N, et al. Nature. 2004 Nov 4;432(7013):112-8. doi: 10.1038/nature03060. Nature. 2004. PMID: 15525991
Tethered poly(A)-binding protein (Pab1p), used as a mimic of a normal 3'-UTR, recruits the termination factor Sup35p (eRF3) and stabilizes nonsense-containing mRNAs. These findings indicate that efficient termination and mRNA stability are dependent on a
Tethered poly(A)-binding protein (Pab1p), used as a mimic of a normal 3'-UTR, recruits the termination factor Sup35p (e …
Early nonsense: mRNA decay solves a translational problem.
Amrani N, Sachs MS, Jacobson A. Amrani N, et al. Nat Rev Mol Cell Biol. 2006 Jun;7(6):415-25. doi: 10.1038/nrm1942. Nat Rev Mol Cell Biol. 2006. PMID: 16723977 Review.
One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination--or nonsense--codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, …
One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination--or nonse …
Functional mapping of the translation-dependent instability element of yeast MATalpha1 mRNA.
Hennigan AN, Jacobson A. Hennigan AN, et al. Mol Cell Biol. 1996 Jul;16(7):3833-43. doi: 10.1128/mcb.16.7.3833. Mol Cell Biol. 1996. PMID: 8668201 Free PMC article.
Our results suggest a model in which the triggering of MATalpha1 mRNA destabilization results from establishment of an interaction between translating ribosomes and a downstream sequence element. Furthermore, our data provide direct molecular evidence for a r …
Our results suggest a model in which the triggering of MATalpha1 mRNA destabilization results from establishment of an interaction be …
The moment when translational control had a theory of everything.
Jacobson A. Jacobson A. Nat Rev Mol Cell Biol. 2017 Jun;18(6):344. doi: 10.1038/nrm.2017.33. Epub 2017 Apr 12. Nat Rev Mol Cell Biol. 2017. PMID: 28400611 Review. No abstract available.
Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.
He F, Li X, Spatrick P, Casillo R, Dong S, Jacobson A. He F, et al. Mol Cell. 2003 Dec;12(6):1439-52. doi: 10.1016/s1097-2765(03)00446-5. Mol Cell. 2003. PMID: 14690598
This analysis revealed that inactivation of Upf1p, Nmd2p, or Upf3p has identical effects on global RNA accumulation; inactivation of Dcp1p or Xrn1p exhibits both common and unique effects on global RNA accumulation but causes upregulation of only a small fraction of transc …
This analysis revealed that inactivation of Upf1p, Nmd2p, or Upf3p has identical effects on global RNA accumulation; inactivation of Dcp1p o …
PTC124 targets genetic disorders caused by nonsense mutations.
Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, Ren H, Moon YC, Corson D, Turpoff AA, Campbell JA, Conn MM, Khan A, Almstead NG, Hedrick J, Mollin A, Risher N, Weetall M, Yeh S, Branstrom AA, Colacino JM, Babiak J, Ju WD, Hirawat S, Northcutt VJ, Miller LL, Spatrick P, He F, Kawana M, Feng H, Jacobson A, Peltz SW, Sweeney HL. Welch EM, et al. Nature. 2007 May 3;447(7140):87-91. doi: 10.1038/nature05756. Epub 2007 Apr 22. Nature. 2007. PMID: 17450125
To address the need for a drug capable of suppressing premature termination, we identified PTC124-a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons. ...The selectivity of PTC124 for premature terminat …
To address the need for a drug capable of suppressing premature termination, we identified PTC124-a new chemical entity that s …
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