Jaeck D - Search Results

1

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs.

Lave T, Dupin S, Schmitt C, Chou RC, Jaeck D, Coassolo P. Lave T, et al. Among authors: jaeck d. J Pharm Sci. 1997 May;86(5):584-90. doi: 10.1021/js960440h. J Pharm Sci. 1997. PMID: 9145383

2

Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance.

Jouin D, Blanchard N, Alexandre E, Delobel F, David-Pierson P, Lavé T, Jaeck D, Richert L, Coassolo P. Jouin D, et al. Among authors: jaeck d. Eur J Pharm Biopharm. 2006 Jul;63(3):347-55. doi: 10.1016/j.ejpb.2006.01.014. Epub 2006 Feb 23. Eur J Pharm Biopharm. 2006. PMID: 16621491

3

Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes.

Blanchard N, Alexandre E, Abadie C, Lavé T, Heyd B, Mantion G, Jaeck D, Richert L, Coassolo P. Blanchard N, et al. Among authors: jaeck d. Xenobiotica. 2005 Jan;35(1):1-15. doi: 10.1080/00498250400021820. Xenobiotica. 2005. PMID: 15788364

4

Estimation of flavin-containing monooxygenase activity in intact hepatocyte monolayers of rat, hamster, rabbit, dog and human by using N-oxidation of benzydamine.

Ubeaud G, Schiller CD, Hurbin F, Jaeck D, Coassolo P. Ubeaud G, et al. Among authors: jaeck d. Eur J Pharm Sci. 1999 Aug;8(4):255-60. doi: 10.1016/s0928-0987(99)00016-0. Eur J Pharm Sci. 1999. PMID: 10425375

5

The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans.

Lavé T, Dupin S, Schmitt C, Valles B, Ubeaud G, Chou RC, Jaeck D, Coassolo P. Lavé T, et al. Among authors: jaeck d. Pharm Res. 1997 Feb;14(2):152-5. doi: 10.1023/a:1012036324237. Pharm Res. 1997. PMID: 9090701

6

Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans.

Lave T, Dupin S, Schmitt M, Kapps M, Meyer J, Morgenroth B, Chou RC, Jaeck D, Coassolo P. Lave T, et al. Among authors: jaeck d. Xenobiotica. 1996 Aug;26(8):839-51. doi: 10.3109/00498259609046754. Xenobiotica. 1996. PMID: 8879148

7

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data.

Ubeaud G, Schmitt C, Jaeck D, Lave T, Coassolo P. Ubeaud G, et al. Among authors: jaeck d. Xenobiotica. 1995 Dec;25(12):1381-90. doi: 10.3109/00498259509061925. Xenobiotica. 1995. PMID: 8719912

8

Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation.

Valles B, Schiller CD, Coassolo P, De Sousa G, Wyss R, Jaeck D, Viger-Chougnet A, Rahmani R. Valles B, et al. Among authors: jaeck d. Drug Metab Dispos. 1995 Oct;23(10):1051-7. Drug Metab Dispos. 1995. PMID: 8654192

9

Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling.

Lave T, Coassolo P, Ubeaud G, Brandt R, Schmitt C, Dupin S, Jaeck D, Chou RC. Lave T, et al. Among authors: jaeck d. Pharm Res. 1996 Jan;13(1):97-101. doi: 10.1023/a:1016037519116. Pharm Res. 1996. PMID: 8668687

10

Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers.

Ubeaud G, Schiller CD, Hurbin F, Jaeck D, Coassolo P. Ubeaud G, et al. Among authors: jaeck d. Eur J Drug Metab Pharmacokinet. 2001 Jan-Jun;26(1-2):37-45. doi: 10.1007/BF03190374. Eur J Drug Metab Pharmacokinet. 2001. PMID: 11554432

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