Jaeger AM - Search Results

1

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.

Jaeger AM, Pemble CW 4th, Sistonen L, Thiele DJ. Jaeger AM, et al. Nat Struct Mol Biol. 2016 Feb;23(2):147-54. doi: 10.1038/nsmb.3150. Epub 2016 Jan 4. Nat Struct Mol Biol. 2016. PMID: 26727490 Free PMC article.

2

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.

Neef DW, Jaeger AM, Thiele DJ. Neef DW, et al. Among authors: jaeger am. Nat Rev Drug Discov. 2011 Dec 1;10(12):930-44. doi: 10.1038/nrd3453. Nat Rev Drug Discov. 2011. PMID: 22129991 Free PMC article. Review.

3

Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding.

Neef DW, Jaeger AM, Thiele DJ. Neef DW, et al. Among authors: jaeger am. G3 (Bethesda). 2013 Aug 7;3(8):1315-24. doi: 10.1534/g3.113.006692. G3 (Bethesda). 2013. PMID: 23733891 Free PMC article.

4

Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.

Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Jaeger AM, et al. J Biol Chem. 2014 Oct 31;289(44):30459-30469. doi: 10.1074/jbc.M114.591578. Epub 2014 Sep 9. J Biol Chem. 2014. PMID: 25204655 Free PMC article.

5

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ. Neef DW, et al. Among authors: jaeger am. Cell Rep. 2014 Nov 6;9(3):955-66. doi: 10.1016/j.celrep.2014.09.056. Epub 2014 Oct 30. Cell Rep. 2014. PMID: 25437552 Free PMC article.

6

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA. Howe MK, et al. Among authors: jaeger am. Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11. Chem Biol. 2014. PMID: 25500222 Free PMC article.

7

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

Gomez-Pastor R, Burchfiel ET, Neef DW, Jaeger AM, Cabiscol E, McKinstry SU, Doss A, Aballay A, Lo DC, Akimov SS, Ross CA, Eroglu C, Thiele DJ. Gomez-Pastor R, et al. Among authors: jaeger am. Nat Commun. 2017 Feb 13;8:14405. doi: 10.1038/ncomms14405. Nat Commun. 2017. PMID: 28194040 Free PMC article.

8

Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity.

Dong B, Jaeger AM, Thiele DJ. Dong B, et al. Among authors: jaeger am. Trends Pharmacol Sci. 2019 Dec;40(12):986-1005. doi: 10.1016/j.tips.2019.10.008. Epub 2019 Nov 11. Trends Pharmacol Sci. 2019. PMID: 31727393 Review.

9

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.

Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Dong B, et al. Among authors: jaeger am. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. doi: 10.1126/scitranslmed.abb5647. Sci Transl Med. 2020. PMID: 33328331 Free PMC article.

10

Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.

Nishida Y, Zhao R, Heese LE, Akiyama H, Patel S, Jaeger AM, Jacamo RO, Kojima K, Ma MCJ, Ruvolo VR, Chachad D, Devine W, Lindquist S, Davis RE, Porco JA Jr, Whitesell L, Andreeff M, Ishizawa J. Nishida Y, et al. Among authors: jaeger am. Leukemia. 2021 Sep;35(9):2469-2481. doi: 10.1038/s41375-021-01308-z. Epub 2021 Jun 14. Leukemia. 2021. PMID: 34127794 Free PMC article. Review.

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