Jaen JC - Search Results

1

Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.

Tecle H, Barrett SD, Lauffer DJ, Augelli-Szafran C, Brann MR, Callahan MJ, Caprathe BW, Davis RE, Doyle PD, Eubanks D, Lipiniski W, Mirzadegan T, Moos WH, Moreland DW, Nelson CB, Pavia MR, Raby C, Schwarz RD, Spencer CJ, Thomas AJ, Jaen JC. Tecle H, et al. Among authors: jaen jc. J Med Chem. 1998 Jul 2;41(14):2524-36. doi: 10.1021/jm960683m. J Med Chem. 1998. PMID: 9651157

2

In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832.

Jaen J, Barrett S, Brann M, Callahan M, Davis R, Doyle P, Eubanks D, Lauffer D, Lauffer L, Lipinski W, et al. Jaen J, et al. Life Sci. 1995;56(11-12):845-52. doi: 10.1016/0024-3205(95)00019-3. Life Sci. 1995. PMID: 10188784

3

Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine.

Caprathe BW, Jaen JC, Wise LD, Heffner TG, Pugsley TA, Meltzer LT, Parvez M. Caprathe BW, et al. Among authors: jaen jc. J Med Chem. 1991 Sep;34(9):2736-46. doi: 10.1021/jm00113a010. J Med Chem. 1991. PMID: 1680195

4

4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.

Jaen JC, Wise LD, Caprathe BW, Tecle H, Bergmeier S, Humblet CC, Heffner TG, Meltzer LT, Pugsley TA. Jaen JC, et al. J Med Chem. 1990 Jan;33(1):311-7. doi: 10.1021/jm00163a051. J Med Chem. 1990. PMID: 1967314

5

Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.

Jaen JC, Caprathe BW, Pugsley TA, Wise LD, Akunne H. Jaen JC, et al. J Med Chem. 1993 Nov 26;36(24):3929-36. doi: 10.1021/jm00076a022. J Med Chem. 1993. PMID: 7902870

6

The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.

Wright JL, Caprathe BW, Downing DM, Glase SA, Heffner TG, Jaen JC, Johnson SJ, Kesten SR, MacKenzie RG, Meltzer LT, et al. Wright JL, et al. Among authors: jaen jc. J Med Chem. 1994 Oct 14;37(21):3523-33. doi: 10.1021/jm00047a010. J Med Chem. 1994. PMID: 7932581

7

Characterization of muscarinic agonists in recombinant cell lines.

Schwarz RD, Davis RE, Jaen JC, Spencer CJ, Tecle H, Thomas AJ. Schwarz RD, et al. Among authors: jaen jc. Life Sci. 1993;52(5-6):465-72. doi: 10.1016/0024-3205(93)90303-k. Life Sci. 1993. PMID: 8382764 Review.

8

Identification and characterization of m4 selective muscarinic antagonists.

Augelli-Szafran CE, Jaen JC, Moreland DW, Nelson CB, Penvose-Yi JR, Schwarz RD. Augelli-Szafran CE, et al. Among authors: jaen jc. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1991-6. doi: 10.1016/s0960-894x(98)00351-5. Bioorg Med Chem Lett. 1998. PMID: 9873472

9

Identification and characterization of m1 selective muscarinic receptor antagonists1.

Augelli-Szafran CE, Blankley CJ, Jaen JC, Moreland DW, Nelson CB, Penvose-Yi JR, Schwarz RD, Thomas AJ. Augelli-Szafran CE, et al. Among authors: jaen jc. J Med Chem. 1999 Feb 11;42(3):356-63. doi: 10.1021/jm980067l. J Med Chem. 1999. PMID: 9986705

10

Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists.

Schwarz RD, Spencer CJ, Jaen JC, Mirzadegan T, Moreland D, Tecle H, Thomas AJ. Schwarz RD, et al. Among authors: jaen jc. Life Sci. 1995;56(11-12):923-9. doi: 10.1016/0024-3205(95)00029-6. Life Sci. 1995. PMID: 10188794

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