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Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time-course of exposure to triazolam.
Rowland Yeo K, Jamei M, Yang J, Tucker GT, Rostami-Hodjegan A. Rowland Yeo K, et al. Among authors: jamei m. Eur J Pharm Sci. 2010 Mar 18;39(5):298-309. doi: 10.1016/j.ejps.2009.12.002. Epub 2009 Dec 16. Eur J Pharm Sci. 2010. PMID: 20025966
Prediction of intestinal first-pass drug metabolism.
Yang J, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Among authors: jamei m. Curr Drug Metab. 2007 Oct;8(7):676-84. doi: 10.2174/138920007782109733. Curr Drug Metab. 2007. PMID: 17979655 Review.
The Simcyp population-based ADME simulator.
Jamei M, Marciniak S, Feng K, Barnett A, Tucker G, Rostami-Hodjegan A. Jamei M, et al. Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):211-23. doi: 10.1517/17425250802691074. Expert Opin Drug Metab Toxicol. 2009. PMID: 19199378 Review.
Population-based mechanistic prediction of oral drug absorption.
Jamei M, Turner D, Yang J, Neuhoff S, Polak S, Rostami-Hodjegan A, Tucker G. Jamei M, et al. AAPS J. 2009 Jun;11(2):225-37. doi: 10.1208/s12248-009-9099-y. Epub 2009 Apr 21. AAPS J. 2009. PMID: 19381840 Free PMC article. Review.
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