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Page 1
The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target.
Ang Z, Castro A, Paruzzo L, Schimdt C, Hasanali ZS, Hayer KE, Stella F, Soldan SS, Torres-Diz M, Kwok C, Sainos PK, Ji K, Krohl PJ, Fine J, Sehgal P, Martinez D, Spangler JB, Riley JL, Vogl DT, Porazzi P, Pillai V, Lieberman PM, Allman D, Ruella M, Thomas-Tikhonenko A. Ang Z, et al. Among authors: spangler jb. bioRxiv [Preprint]. 2026 Jan 26:2026.01.14.698748. doi: 10.64898/2026.01.14.698748. bioRxiv. 2026. PMID: 41648131 Free PMC article. Preprint.
Dynamics and variegation in the Treg response to Interleukin-2.
Seddu K, Chowdhary K, Henderson M, Tomala J, Casey O, Cao Y, Mathis D, Spangler JB, Benoist C. Seddu K, et al. Among authors: spangler jb. Proc Natl Acad Sci U S A. 2025 Nov 25;122(47):e2518991122. doi: 10.1073/pnas.2518991122. Epub 2025 Nov 20. Proc Natl Acad Sci U S A. 2025. PMID: 41264258
Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion.
Kilic IB, Weberova P, VanDyke D, Sirova M, Kubesova K, Fabilane CS, Mazhara V, Liu K, Behalova K, Ptacek B, Rihova B, Spangler JB, Kovar M. Kilic IB, et al. Among authors: spangler jb. J Immunother Cancer. 2025 Aug 11;13(8):e010465. doi: 10.1136/jitc-2024-010465. J Immunother Cancer. 2025. PMID: 40789741 Free PMC article.
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas.
Sehgal P, Naqvi AS, Higgins M, Liu J, Harvey K, Jarroux J, Kim T, Mankaliye B, Mishra P, Watterson G, Fine J, Davis J, Hayer KE, Castro A, Mogbo A, Drummer C 4th, Martinez D, Koptyra MP, Ang Z, Wang K, Farrel A, Quesnel-Vallieres M, Barash Y, Spangler JB, Rokita JL, Resnick AC, Tilgner HU, De Raedt T, Powell DJ Jr, Thomas-Tikhonenko A. Sehgal P, et al. Among authors: spangler jb. Cell Rep. 2025 Aug 26;44(8):116099. doi: 10.1016/j.celrep.2025.116099. Epub 2025 Aug 7. Cell Rep. 2025. PMID: 40782352 Free PMC article.
Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism.
Liu H, Cai Y, Shi L, Pillai M, Das N, Tarbox HE, Ge Y, Yue K, Yang X, Rath P, Badiee M, Fabilane CS, Spangler JB, Bedford MT, Myong S, Fried SD, Ding X, Leung AKL. Liu H, et al. Among authors: spangler jb. bioRxiv [Preprint]. 2025 Jul 5:2025.07.03.659157. doi: 10.1101/2025.07.03.659157. bioRxiv. 2025. PMID: 40631075 Free PMC article. Preprint.
88 results