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Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F. Prieto Huarcaya S, et al. Among authors: dobert jp. Autophagy. 2022 May;18(5):1127-1151. doi: 10.1080/15548627.2022.2045534. Epub 2022 Apr 28. Autophagy. 2022. PMID: 35287553 Free PMC article.
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.
Balta D, Varghese A, Prieto Huarcaya S, Di Spiezio A, Marques ARA, Akdaş EY, Tabakacilar D, Drobny A, Werner C, Xiang W, Mächtel R, Dobert JP, Fejtova A, Richter F, Küspert M, Arnold P, Saftig P, Zunke F. Balta D, et al. Among authors: dobert jp. Mol Neurodegener. 2025 Aug 29;20(1):95. doi: 10.1186/s13024-025-00886-1. Mol Neurodegener. 2025. PMID: 40883786 Free PMC article.
Activation and Purification of ß-Glucocerebrosidase by Exploiting its Transporter LIMP-2 - Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease.
Dobert JP, Bub S, Mächtel R, Januliene D, Steger L, Regensburger M, Wilfling S, Chen JX, Dejung M, Plötz S, Hehr U, Moeller A, Arnold P, Zunke F. Dobert JP, et al. Adv Sci (Weinh). 2024 Jul;11(25):e2401641. doi: 10.1002/advs.202401641. Epub 2024 Apr 26. Adv Sci (Weinh). 2024. PMID: 38666485 Free PMC article.
13 results