Jan LY[au] - Search Results

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A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane.

Teo CF, Tuomivaara ST, van Hilten N, Crottès D, Jan YN, Grabe M, Jan LY. Teo CF, et al. Among authors: jan ly. Proc Natl Acad Sci U S A. 2025 Nov 4;122(44):e2516822122. doi: 10.1073/pnas.2516822122. Epub 2025 Oct 30. Proc Natl Acad Sci U S A. 2025. PMID: 41166415 Free PMC article.

Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila.

Guo Y, Li T, Tuomivaara ST, Teo CF, Feng S, Chalkley RJ, Zhu R, Cheng T, Li KH, Chen W, Simon A, Jin P, Younger S, Yong AJH, Li K, Li K, Burlingame AL, Jan LY, Jan YN. Guo Y, et al. Among authors: jan ly. Neuron. 2025 Oct 15;113(20):3352-3362.e5. doi: 10.1016/j.neuron.2025.09.007. Epub 2025 Oct 3. Neuron. 2025. PMID: 41045928 Free article.

Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia-mediated axon degeneration.

Zhang X, Chen W, Wang Y, Tu X, Zhang X, Davis RL, Jan LY, Jan YN. Zhang X, et al. Among authors: jan ly. bioRxiv [Preprint]. 2025 Sep 3:2025.08.29.673168. doi: 10.1101/2025.08.29.673168. bioRxiv. 2025. PMID: 40950227 Free PMC article. Preprint.

A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane.

Teo CF, Tuomivaara ST, van Hilten N, Crottès D, Jan YN, Grabe M, Jan LY. Teo CF, et al. Among authors: jan ly. bioRxiv [Preprint]. 2025 Jun 27:2025.06.25.661602. doi: 10.1101/2025.06.25.661602. bioRxiv. 2025. Update in: Proc Natl Acad Sci U S A. 2025 Nov 4;122(44):e2516822122. doi: 10.1073/pnas.2516822122. PMID: 40667283 Free PMC article. Updated. Preprint.

Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families.

Jan LY, Jan YN. Jan LY, et al. Nat Struct Mol Biol. 2025 Feb;32(2):222-236. doi: 10.1038/s41594-024-01444-x. Epub 2024 Dec 23. Nat Struct Mol Biol. 2025. PMID: 39715905 Review.

SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.

Tuomivaara ST, Teo CF, Jan YN, Wiita AP, Jan LY. Tuomivaara ST, et al. Among authors: jan ly. Commun Biol. 2024 Aug 29;7(1):1060. doi: 10.1038/s42003-024-06729-x. Commun Biol. 2024. PMID: 39210032 Free PMC article.

TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.

Zubia MV, Yong AJH, Holtz KM, Huang EJ, Jan YN, Jan LY. Zubia MV, et al. Among authors: jan ly. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2311831121. doi: 10.1073/pnas.2311831121. Epub 2024 Jun 28. Proc Natl Acad Sci U S A. 2024. PMID: 38941274 Free PMC article.

A personal perspective of the voltage-gated potassium channel studies.

Jan LY, Jan YN. Jan LY, et al. Nat Struct Mol Biol. 2024 Apr;31(4):580-581. doi: 10.1038/s41594-024-01267-w. Nat Struct Mol Biol. 2024. PMID: 38548955 No abstract available.

Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.

Li K, Guo Y, Wang Y, Zhu R, Chen W, Cheng T, Zhang X, Jia Y, Liu T, Zhang W, Jan LY, Jan YN. Li K, et al. Among authors: jan ly. Nat Cell Biol. 2024 Mar;26(3):393-403. doi: 10.1038/s41556-024-01353-7. Epub 2024 Feb 22. Nat Cell Biol. 2024. PMID: 38388853 Free PMC article.

Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.

Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY. Feng S, et al. Among authors: jan ly. Nat Commun. 2023 Aug 12;14(1):4874. doi: 10.1038/s41467-023-40410-x. Nat Commun. 2023. PMID: 37573365 Free PMC article.

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