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OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. Marchetti C, et al. Among authors: janciauskiene s. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29. Proc Natl Acad Sci U S A. 2018. PMID: 29378952 Free PMC article.
Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase.
Jonigk D, Al-Omari M, Maegel L, Müller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S. Jonigk D, et al. Among authors: janciauskiene s. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15007-12. doi: 10.1073/pnas.1309648110. Epub 2013 Aug 23. Proc Natl Acad Sci U S A. 2013. PMID: 23975926 Free PMC article.
Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.
Hecker A, Küllmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda EK, Lochnit G, Grau V. Hecker A, et al. Among authors: janciauskiene s. J Immunol. 2015 Sep 1;195(5):2325-34. doi: 10.4049/jimmunol.1400974. Epub 2015 Jul 22. J Immunol. 2015. PMID: 26202987
Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors.
Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V. Siebers K, et al. Among authors: janciauskiene s. Front Immunol. 2018 Apr 25;9:877. doi: 10.3389/fimmu.2018.00877. eCollection 2018. Front Immunol. 2018. PMID: 29922281 Free PMC article.
SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player.
Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agné A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V. Zakrzewicz A, et al. Among authors: janciauskiene s. Front Immunol. 2019 Apr 4;10:664. doi: 10.3389/fimmu.2019.00664. eCollection 2019. Front Immunol. 2019. PMID: 31019507 Free PMC article.
249 results