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Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J Med Chem. 2012 Mar 22;55(6):2641-8. doi: 10.1021/jm2014698. Epub 2012 Mar 5.
J Med Chem. 2012.
PMID: 22339127
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Xiang Y, Hirth B, Asmussen G, Biemann HP, Bishop KA, Good A, Fitzgerald M, Gladysheva T, Jain A, Jancsics K, Liu J, Metz M, Papoulis A, Skerlj R, Stepp JD, Wei RR.
Xiang Y, et al. Among authors: jancsics k.
Bioorg Med Chem Lett. 2011 May 15;21(10):3050-6. doi: 10.1016/j.bmcl.2011.03.030. Epub 2011 Mar 16.
Bioorg Med Chem Lett. 2011.
PMID: 21507633
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SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids.
Mason P, Liang B, Li L, Fremgen T, Murphy E, Quinn A, Madden SL, Biemann HP, Wang B, Cohen A, Komarnitsky S, Jancsics K, Hirth B, Cooper CG, Lee E, Wilson S, Krumbholz R, Schmid S, Xiang Y, Booker M, Lillie J, Carter K.
Mason P, et al. Among authors: jancsics k.
PLoS One. 2012;7(3):e33823. doi: 10.1371/journal.pone.0033823. Epub 2012 Mar 22.
PLoS One. 2012.
PMID: 22457791
Free PMC article.
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