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Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B. Janke C, et al. Science. 2005 Jun 17;308(5729):1758-62. doi: 10.1126/science.1113010. Epub 2005 May 12. Science. 2005. PMID: 15890843
A targeted multienzyme mechanism for selective microtubule polyglutamylation.
van Dijk J, Rogowski K, Miro J, Lacroix B, Eddé B, Janke C. van Dijk J, et al. Mol Cell. 2007 May 11;26(3):437-48. doi: 10.1016/j.molcel.2007.04.012. Mol Cell. 2007. PMID: 17499049
Polyglutamylation is a post-translational modification with a broad range of substrates.
van Dijk J, Miro J, Strub JM, Lacroix B, van Dorsselaer A, Edde B, Janke C. van Dijk J, et al. J Biol Chem. 2008 Feb 15;283(7):3915-22. doi: 10.1074/jbc.M705813200. Epub 2007 Nov 28. J Biol Chem. 2008. PMID: 18045879
CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites.
Bieling P, Kandels-Lewis S, Telley IA, van Dijk J, Janke C, Surrey T. Bieling P, et al. J Cell Biol. 2008 Dec 29;183(7):1223-33. doi: 10.1083/jcb.200809190. Epub 2008 Dec 22. J Cell Biol. 2008. PMID: 19103809 Free PMC article.
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.
Rogowski K, Juge F, van Dijk J, Wloga D, Strub JM, Levilliers N, Thomas D, Bré MH, Van Dorsselaer A, Gaertig J, Janke C. Rogowski K, et al. Cell. 2009 Jun 12;137(6):1076-87. doi: 10.1016/j.cell.2009.05.020. Cell. 2009. PMID: 19524510
Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
Lacroix B, van Dijk J, Gold ND, Guizetti J, Aldrian-Herrada G, Rogowski K, Gerlich DW, Janke C. Lacroix B, et al. J Cell Biol. 2010 Jun 14;189(6):945-54. doi: 10.1083/jcb.201001024. Epub 2010 Jun 7. J Cell Biol. 2010. PMID: 20530212 Free PMC article.
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