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Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway.
J Am Chem Soc. 2013 Feb 6;135(5):1816-22. doi: 10.1021/ja309557s. Epub 2013 Jan 29.
J Am Chem Soc. 2013.
PMID: 23316732
Free PMC article.
Isoprenoid biosynthesis via the MEP pathway: in vivo Mössbauer spectroscopy identifies a [4Fe-4S]2+ center with unusual coordination sphere in the LytB protein.
Seemann M, Janthawornpong K, Schweizer J, Böttger LH, Janoschka A, Ahrens-Botzong A, Tambou EN, Rotthaus O, Trautwein AX, Rohmer M.
Seemann M, et al. Among authors: janthawornpong k.
J Am Chem Soc. 2009 Sep 23;131(37):13184-5. doi: 10.1021/ja9012408.
J Am Chem Soc. 2009.
PMID: 19708647
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Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.
Borel F, Barbier E, Krasutsky S, Janthawornpong K, Chaignon P, Poulter CD, Ferrer JL, Seemann M.
Borel F, et al. Among authors: janthawornpong k.
Chembiochem. 2017 Nov 2;18(21):2137-2144. doi: 10.1002/cbic.201700363. Epub 2017 Oct 2.
Chembiochem. 2017.
PMID: 28862365
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Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.
Ahrens-Botzong A, Janthawornpong K, Wolny JA, Tambou EN, Rohmer M, Krasutsky S, Poulter CD, Schünemann V, Seemann M.
Ahrens-Botzong A, et al. Among authors: janthawornpong k.
Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11976-9. doi: 10.1002/anie.201104562. Epub 2011 Oct 19.
Angew Chem Int Ed Engl. 2011.
PMID: 22012762
Free PMC article.
No abstract available.
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