January CT - Search Results

1

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

Rajamani S, Eckhardt LL, Valdivia CR, Klemens CA, Gillman BM, Anderson CL, Holzem KM, Delisle BP, Anson BD, Makielski JC, January CT. Rajamani S, et al. Among authors: january ct. Br J Pharmacol. 2006 Nov;149(5):481-9. doi: 10.1038/sj.bjp.0706892. Epub 2006 Sep 11. Br J Pharmacol. 2006. PMID: 16967046 Free PMC article.

2

The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.

Mbai M, Rajamani S, January CT. Mbai M, et al. Among authors: january ct. Cardiovasc Res. 2002 Sep;55(4):799-805. doi: 10.1016/s0008-6363(02)00448-0. Cardiovasc Res. 2002. PMID: 12176129

3

Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C.

Delisle BP, Anderson CL, Balijepalli RC, Anson BD, Kamp TJ, January CT. Delisle BP, et al. Among authors: january ct. J Biol Chem. 2003 Sep 12;278(37):35749-54. doi: 10.1074/jbc.M305787200. Epub 2003 Jul 1. J Biol Chem. 2003. PMID: 12837749 Free article.

4

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.

Anson BD, Ackerman MJ, Tester DJ, Will ML, Delisle BP, Anderson CL, January CT. Anson BD, et al. Among authors: january ct. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2434-41. doi: 10.1152/ajpheart.00891.2003. Epub 2004 Feb 19. Am J Physiol Heart Circ Physiol. 2004. PMID: 14975928 Free article.

5

Biology of cardiac arrhythmias: ion channel protein trafficking.

Delisle BP, Anson BD, Rajamani S, January CT. Delisle BP, et al. Among authors: january ct. Circ Res. 2004 Jun 11;94(11):1418-28. doi: 10.1161/01.RES.0000128561.28701.ea. Circ Res. 2004. PMID: 15192037 Review.

6

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.

Eckhardt LL, Rajamani S, January CT. Eckhardt LL, et al. Among authors: january ct. Br J Pharmacol. 2005 May;145(1):3-4. doi: 10.1038/sj.bjp.0706143. Br J Pharmacol. 2005. PMID: 15711590 Free PMC article.

7

Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome.

Delisle BP, Slind JK, Kilby JA, Anderson CL, Anson BD, Balijepalli RC, Tester DJ, Ackerman MJ, Kamp TJ, January CT. Delisle BP, et al. Among authors: january ct. Mol Pharmacol. 2005 Jul;68(1):233-40. doi: 10.1124/mol.105.012914. Epub 2005 Apr 25. Mol Pharmacol. 2005. PMID: 15851652

8

Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).

Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT. Rajamani S, et al. Among authors: january ct. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88. doi: 10.1152/ajpheart.00777.2005. Epub 2005 Oct 14. Am J Physiol Heart Circ Physiol. 2006. PMID: 16227340 Free article.

9

Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.

Kawakami K, Nagatomo T, Abe H, Kikuchi K, Takemasa H, Anson BD, Delisle BP, January CT, Nakashima Y. Kawakami K, et al. Among authors: january ct. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508. Br J Pharmacol. 2006. PMID: 16314852 Free PMC article.

10

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism.

Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, Gong Q, Zhou Z, Ackerman MJ, January CT. Anderson CL, et al. Among authors: january ct. Circulation. 2006 Jan 24;113(3):365-73. doi: 10.1161/CIRCULATIONAHA.105.570200. Circulation. 2006. PMID: 16432067

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