Jarolimek W - Search Results

1

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.

Chang J, Lucas MC, Leonte LE, Garcia-Montolio M, Singh LB, Findlay AD, Deodhar M, Foot JS, Jarolimek W, Timpson P, Erler JT, Cox TR. Chang J, et al. Among authors: jarolimek w. Oncotarget. 2017 Apr 18;8(16):26066-26078. doi: 10.18632/oncotarget.15257. Oncotarget. 2017. PMID: 28199967 Free PMC article.

2

PXS-4681A, a potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo.

Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, McDonald IA, Turner CI, Zhou W, Jarolimek W. Foot JS, et al. Among authors: jarolimek w. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74. doi: 10.1124/jpet.113.207613. Epub 2013 Aug 13. J Pharmacol Exp Ther. 2013. PMID: 23943052

3

Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration.

Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. Schilter HC, et al. Among authors: jarolimek w. Respir Res. 2015 Mar 20;16(1):42. doi: 10.1186/s12931-015-0200-z. Respir Res. 2015. PMID: 25889951 Free PMC article.

4

The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts.

Schilter H, Cantemir-Stone CZ, Leksa V, Ohradanova-Repic A, Findlay AD, Deodhar M, Stockinger H, Song X, Molloy M, Marsh CB, Jarolimek W. Schilter H, et al. Among authors: jarolimek w. Immunol Lett. 2015 Jun;165(2):90-101. doi: 10.1016/j.imlet.2015.04.003. Epub 2015 Apr 27. Immunol Lett. 2015. PMID: 25929803 Free article.

5

The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model.

Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM. Jarnicki AG, et al. Among authors: jarolimek w. Br J Pharmacol. 2016 Nov;173(22):3161-3175. doi: 10.1111/bph.13573. Epub 2016 Oct 12. Br J Pharmacol. 2016. PMID: 27495192 Free PMC article.

6

Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation.

Becchi S, Buson A, Foot J, Jarolimek W, Balleine BW. Becchi S, et al. Among authors: jarolimek w. Br J Pharmacol. 2017 Jul;174(14):2302-2317. doi: 10.1111/bph.13832. Epub 2017 Jun 10. Br J Pharmacol. 2017. PMID: 28437839 Free PMC article.

7

The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.

Schilter H, Findlay AD, Perryman L, Yow TT, Moses J, Zahoor A, Turner CI, Deodhar M, Foot JS, Zhou W, Greco A, Joshi A, Rayner B, Townsend S, Buson A, Jarolimek W. Schilter H, et al. Among authors: jarolimek w. J Cell Mol Med. 2019 Mar;23(3):1759-1770. doi: 10.1111/jcmm.14074. Epub 2018 Dec 9. J Cell Mol Med. 2019. PMID: 30536539 Free PMC article.

8

Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.

Findlay AD, Foot JS, Buson A, Deodhar M, Jarnicki AG, Hansbro PM, Liu G, Schilter H, Turner CI, Zhou W, Jarolimek W. Findlay AD, et al. Among authors: jarolimek w. J Med Chem. 2019 Nov 14;62(21):9874-9889. doi: 10.1021/acs.jmedchem.9b01283. Epub 2019 Oct 16. J Med Chem. 2019. PMID: 31580073

9

Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice.

Leiva O, Ng SK, Matsuura S, Chitalia V, Lucero H, Findlay A, Turner C, Jarolimek W, Ravid K. Leiva O, et al. Among authors: jarolimek w. Int J Hematol. 2019 Dec;110(6):699-708. doi: 10.1007/s12185-019-02751-6. Epub 2019 Oct 21. Int J Hematol. 2019. PMID: 31637674 Free PMC article.

10

An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies.

Findlay A, Turner C, Schilter H, Deodhar M, Zhou W, Perryman L, Foot J, Zahoor A, Yao Y, Hamilton R, Brock M, Raso C, Stolp J, Galati M, Hamprecht D, Charlton B, Jarolimek W. Findlay A, et al. Among authors: jarolimek w. Clin Transl Med. 2021 Nov;11(11):e572. doi: 10.1002/ctm2.572. Clin Transl Med. 2021. PMID: 34841699 Free PMC article. No abstract available.

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