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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.
Jarrett JT, Berger EP, Lansbury PT Jr. Jarrett JT, et al. Biochemistry. 1993 May 11;32(18):4693-7. doi: 10.1021/bi00069a001. Biochemistry. 1993. PMID: 8490014
Control of adenosylmethionine-dependent radical generation in biotin synthase: a kinetic and thermodynamic analysis of substrate binding to active and inactive forms of BioB.
Ugulava NB, Frederick KK, Jarrett JT. Ugulava NB, et al. Among authors: jarrett jt. Biochemistry. 2003 Mar 11;42(9):2708-19. doi: 10.1021/bi0261084. Biochemistry. 2003. PMID: 12614166 Free PMC article.
Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase.
Taylor AM, Stoll S, Britt RD, Jarrett JT. Taylor AM, et al. Among authors: jarrett jt. Biochemistry. 2011 Sep 20;50(37):7953-63. doi: 10.1021/bi201042r. Epub 2011 Aug 25. Biochemistry. 2011. PMID: 21859080 Free PMC article.
Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules.
Farrar CE, Siu KK, Howell PL, Jarrett JT. Farrar CE, et al. Among authors: jarrett jt. Biochemistry. 2010 Nov 23;49(46):9985-96. doi: 10.1021/bi101023c. Epub 2010 Nov 1. Biochemistry. 2010. PMID: 20961145 Free PMC article.
A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly.
Reyda MR, Fugate CJ, Jarrett JT. Reyda MR, et al. Among authors: jarrett jt. Biochemistry. 2009 Nov 17;48(45):10782-92. doi: 10.1021/bi901393t. Biochemistry. 2009. PMID: 19821612 Free PMC article.
Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase.
Farrar CE, Jarrett JT. Farrar CE, et al. Among authors: jarrett jt. Biochemistry. 2009 Mar 24;48(11):2448-58. doi: 10.1021/bi8022569. Biochemistry. 2009. PMID: 19199517 Free PMC article.
9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase.
Taylor AM, Farrar CE, Jarrett JT. Taylor AM, et al. Among authors: jarrett jt. Biochemistry. 2008 Sep 2;47(35):9309-17. doi: 10.1021/bi801035b. Epub 2008 Aug 9. Biochemistry. 2008. PMID: 18690713 Free PMC article.
Interaction of Escherichia coli cobalamin-dependent methionine synthase and its physiological partner flavodoxin: binding of flavodoxin leads to axial ligand dissociation from the cobalamin cofactor.
Hoover DM, Jarrett JT, Sands RH, Dunham WR, Ludwig ML, Matthews RG. Hoover DM, et al. Among authors: jarrett jt. Biochemistry. 1997 Jan 7;36(1):127-38. doi: 10.1021/bi961693s. Biochemistry. 1997. PMID: 8993326
Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin.
Jarrett JT, Huang S, Matthews RG. Jarrett JT, et al. Biochemistry. 1998 Apr 21;37(16):5372-82. doi: 10.1021/bi9730893. Biochemistry. 1998. PMID: 9548919
Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase.
Jarrett JT, Choi CY, Matthews RG. Jarrett JT, et al. Biochemistry. 1997 Dec 16;36(50):15739-48. doi: 10.1021/bi971987t. Biochemistry. 1997. PMID: 9398303
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