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Cryo-EM reveals conformational variability in the SARS-CoV-2 spike protein RBD induced by two broadly neutralizing monoclonal antibodies.
Rencilin CF, Chatterjee A, Ansari MY, Deshpande S, Mukherjee S, Singh R, Jayatheertha SB, Reddy PM, Hingankar N, Varadarajan R, Bhattacharya J, Dutta S. Rencilin CF, et al. Among authors: bhattacharya j. RSC Adv. 2025 May 6;15(18):14385-14399. doi: 10.1039/d5ra00373c. eCollection 2025 Apr 28. RSC Adv. 2025. PMID: 40330036 Free PMC article.
This flexibility also influences its interactions with the neutralizing antibodies, yet its role in the antibody complexes remains understudied. In this study, we used cryo-electron microscopy to investigate the structural properties of two broadly neutralizing mono …
This flexibility also influences its interactions with the neutralizing antibodies, yet its role in the antibody complexes remains un …
Trends of humoral immune responses to heterologous antigenic exposure due to vaccination & omicron SARS-CoV-2 infection: Implications for boosting.
Batra G, Murugesan DR, Raghavan S, Chattopadhyay S, Mehdi F, Ayushi, Gosain M, Singh S, Das SJ, Deshpande S, Sonar S, Jakhar K, Bhattacharya J, Mani S, Pandey AK, Sankalp, Goswami S, Das A, Dwivedi T, Sharma N, Kumar S, Sharma P, Kapoor S, Kshetrapa P, Wadhwa N, Thiruvengadam R, Kumar R, Gupta R, Garg PK, Bhatnagar S. Batra G, et al. Among authors: bhattacharya j. Indian J Med Res. 2023 Jun;157(6):509-518. doi: 10.4103/ijmr.ijmr_2521_22. Indian J Med Res. 2023. PMID: 37322634 Free PMC article.
The main outcome was durability and augmentation of the humoral immune response as determined by anti-receptor-binding domain (RBD) immunoglobulin G (IgG) concentrations, anti-nucleocapsid antibodies and anti-omicron RBD antibodies. Live virus neutralization assay was cond …
The main outcome was durability and augmentation of the humoral immune response as determined by anti-receptor-binding domain (RBD) immunogl …
Ancestral SARS-CoV-2-Driven Antibody Repertoire Diversity in an Unvaccinated Individual Correlates with Expanded Neutralization Breadth.
Deshpande S, Ansari MY, Sutar J, Das P, Hingankar N, Mukherjee S, Jayal P, Singh S, Anantharaj A, Singh J, Chattopadhyay S, Raghavan S, Gosain M, Chauhan S, Shrivas S, Prasad C, Chauhan S, Sharma N, Jana P, Thiruvengadam R, Kshetrapal P, Wadhwa N, Das B, Batra G, Medigeshi G, Sok D, Bhatnagar S, Garg PK, Bhattacharya J. Deshpande S, et al. Among authors: bhattacharya j. Microbiol Spectr. 2023 Mar 22;11(2):e0433222. doi: 10.1128/spectrum.04332-22. Online ahead of print. Microbiol Spectr. 2023. PMID: 36946746 Free PMC article.
Understanding the quality of immune repertoire triggered during natural infection can provide vital clues that form the basis for development of a humoral immune response in some individuals capable of broadly neutralizing pan-SARS-CoV-2 variants. In the present study, we …
Understanding the quality of immune repertoire triggered during natural infection can provide vital clues that form the basis for developmen …
A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant.
Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, Ansari MY, Burns A, Barman S, Zhao F, Mukherjee S, Torres JL, Chattopadhyay S, Mehdi F, Sutar J, Rathore DK, Pargai K, Singh J, Sonar S, Jakhar K, Dandotiya J, Bhattacharyya S, Mani S, Samal S, Singh S, Kshetrapal P, Thiruvengadam R, Batra G, Medigeshi G, Ward AB, Bhatnagar S, Awasthi A, Sok D, Bhattacharya J. Hingankar N, et al. Among authors: bhattacharya j. PLoS Pathog. 2022 Apr 28;18(4):e1010465. doi: 10.1371/journal.ppat.1010465. eCollection 2022 Apr. PLoS Pathog. 2022. PMID: 35482816 Free PMC article.
Here we report the isolation of five neutralizing mAbs from an Indian convalescent donor, out of which two (THSC20.HVTR04 and THSC20.HVTR26) showed potent neutralization of SARS-CoV-2 VOCs at picomolar concentrations, including the Delta variant (B.1.617.2). ...
Here we report the isolation of five neutralizing mAbs from an Indian convalescent donor, out of which two (THSC20.HVTR04 and THSC20. …
Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses.
Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, Shrivastava T, Samal S, Rathna Murugesan D, Koundinya Desiraju B, Kshetrapal P, Pandey R, Scaria V, Kumar Malik P, Taneja J, Binayke A, Vohra T, Zaheer A, Rathore D, Ahmad Khan N, Shaman H, Ahmed S, Kumar R, Deshpande S, Subramani C, Wadhwa N, Gupta N, Pandey AK, Bhattacharya J, Agrawal A, Vrati S, Bhatnagar S, Garg PK; Department of Biotechnology India Consortium for COVID-19 research. Thiruvengadam R, et al. Among authors: bhattacharya j. Lancet Infect Dis. 2022 Apr;22(4):473-482. doi: 10.1016/S1473-3099(21)00680-0. Epub 2021 Nov 25. Lancet Infect Dis. 2022. PMID: 34838183 Free PMC article.
Additionally, we tested in-vitro live-virus neutralisation and T-cell immune responses to the spike protein of the wild-type SARS-CoV-2 and VOCs among healthy (anti-nucleocapsid antibody negative) recipients of the ChAdOx1 nCoV-19 vaccine. ...Among 49 healthy, fully vaccin …
Additionally, we tested in-vitro live-virus neutralisation and T-cell immune responses to the spike protein of the wild-type SARS-CoV …
Geospatial HIV-1 subtype C gp120 sequence diversity and its predicted impact on broadly neutralizing antibody sensitivity.
Sutar J, Deshpande S, Mullick R, Hingankar N, Patel V, Bhattacharya J. Sutar J, et al. Among authors: bhattacharya j. PLoS One. 2021 May 24;16(5):e0251969. doi: 10.1371/journal.pone.0251969. eCollection 2021. PLoS One. 2021. PMID: 34029329 Free PMC article.
Evolving diversity in globally circulating HIV-1 subtypes presents a formidable challenge in defining and developing neutralizing antibodies for prevention and treatment. HIV-1 subtype C is responsible for majority of global HIV-1 infections. In the present study, we exami …
Evolving diversity in globally circulating HIV-1 subtypes presents a formidable challenge in defining and developing neutralizing ant …
Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities.
Mullick R, Sutar J, Hingankar N, Deshpande S, Thakar M, Sahay S, Ringe RP, Mukhopadhyay S, Patil A, Bichare S, Murugavel KG, Srikrishnan AK, Goyal R, Sok D, Bhattacharya J. Mullick R, et al. Among authors: bhattacharya j. Retrovirology. 2021 May 14;18(1):12. doi: 10.1186/s12977-021-00556-2. Retrovirology. 2021. PMID: 33990195 Free PMC article.
BACKGROUND: The potential use of the broadly neutralizing monoclonal antibodies (bnAbs) towards prophylaxis and treatment to HIV-1 is currently being explored. ...However, inconsistent trend in neutralization susceptibility was observed, when pseudoviruses expressin …
BACKGROUND: The potential use of the broadly neutralizing monoclonal antibodies (bnAbs) towards prophylaxis and treatment to HIV-1 is …
Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer.
Kumar R, Deshpande S, Sewall LM, Ozorowski G, Cottrell CA, Lee WH, Holden LG, Richey ST, Chandrawacar AS, Dhiman K, Ashish, Kumar V, Ahmed S, Hingankar N, Kumar N, Murugavel KG, Srikrishnan AK, Sok D, Ward AB, Bhattacharya J. Kumar R, et al. Among authors: bhattacharya j. PLoS Pathog. 2021 Apr 7;17(4):e1008977. doi: 10.1371/journal.ppat.1008977. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33826683 Free PMC article.
In the present study, we examined the magnitude and specificity of autologous neutralizing antibodies induced in rabbits by a novel HIV-1 clade C Env protein (1PGE-THIVC) vis-a-vis those developed in an elite neutralizer from whom the env sequence was obtained that …
In the present study, we examined the magnitude and specificity of autologous neutralizing antibodies induced in rabbits by a novel H …
Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8.
Sutar J, Padwal V, Sonawani A, Nagar V, Patil P, Kulkarni B, Hingankar N, Deshpande S, Idicula-Thomas S, Jagtap D, Bhattacharya J, Bandivdekar A, Patel V. Sutar J, et al. Among authors: bhattacharya j. Virus Res. 2019 Nov;273:197763. doi: 10.1016/j.virusres.2019.197763. Epub 2019 Sep 22. Virus Res. 2019. PMID: 31553924
Membrane proximal external region (MPER) is an attractive target for broadly neutralizing antibody (bNAb) based therapies. However, information on MPER sequence diversity from India is meagre due to limited sampling of primary viral sequences. ...ELISA, Surface Plasmon Res …
Membrane proximal external region (MPER) is an attractive target for broadly neutralizing antibody (bNAb) based therapies. However, i …
Broadly neutralizing antibodies in HIV-1 treatment and prevention.
Kumar R, Qureshi H, Deshpande S, Bhattacharya J. Kumar R, et al. Among authors: bhattacharya j. Ther Adv Vaccines Immunother. 2018 Oct 12;6(4):61-68. doi: 10.1177/2515135518800689. eCollection 2018 Aug. Ther Adv Vaccines Immunother. 2018. PMID: 30345419 Free PMC article. Review.
Antibodies that naturally develop in some individuals infected with human immunodeficiency virus 1 (HIV-1) and are capable of broadly neutralizing diverse strains of HIV-1 are useful for two applications: they can inform the rational design of vaccine immunogens, and they …
Antibodies that naturally develop in some individuals infected with human immunodeficiency virus 1 (HIV-1) and are capable of broadly neu …
29 results