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Adeno-Associated Virus Gene Therapy Development: Early Planning and Regulatory Considerations to Advance the Platform Vector Gene Therapy Program.
Lomash RM, Dehdashti J, Shchelochkov OA, Chandler RJ, Li L, Manoli I, Sloan JL, Terse P, Xu X, Saade D, Stan R; PaVe-GT team; Brooks PJ, Lo DC, Bönnemann CG, Venditti CP, Pariser AR, Ottinger EA. Lomash RM, et al. Among authors: dehdashti j. Hum Gene Ther. 2025 Mar;36(5-6):653-662. doi: 10.1089/hum.2024.230. Epub 2025 Feb 20. Hum Gene Ther. 2025. PMID: 39976996 Free PMC article.
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction.
Chen FW, Davies JP, Calvo R, Chaudhari J, Dolios G, Taylor MK, Patnaik S, Dehdashti J, Mull R, Dranchack P, Wang A, Xu X, Hughes E, Southall N, Ferrer M, Wang R, Marugan JJ, Ioannou YA. Chen FW, et al. Among authors: dehdashti j. iScience. 2022 Aug 14;25(9):104941. doi: 10.1016/j.isci.2022.104941. eCollection 2022 Sep 16. iScience. 2022. PMID: 36065186 Free PMC article.