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AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation.
Hanlon PR, Ganem LG, Cho YC, Yamamoto M, Jefcoate CR. Hanlon PR, et al. Toxicol Appl Pharmacol. 2003 May 15;189(1):11-27. doi: 10.1016/s0041-008x(03)00083-8. Toxicol Appl Pharmacol. 2003. PMID: 12758056
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc.
Moore RW, Jefcoate CR, Peterson RE. Moore RW, et al. Toxicol Appl Pharmacol. 1991 Jun 1;109(1):85-97. doi: 10.1016/0041-008x(91)90193-i. Toxicol Appl Pharmacol. 1991. PMID: 1645482
Differences in the modulation of P450IA1 and epoxide hydratase expression by benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse embryo versus mouse hepatoma-derived cell lines.
Christou M, Stewart P, Pottenger LH, Fahl WE, Jefcoate CR. Christou M, et al. Carcinogenesis. 1990 Oct;11(10):1691-8. doi: 10.1093/carcin/11.10.1691. Carcinogenesis. 1990. PMID: 2208584
In addition, the microsomal epoxide hydratase (EHm) in Hepa-1 cells is far less effective in dihydrodiol (diol) formation compared to that in 10T1/2 microsomes [Pottenger, L.H. and Jefcoate, C.R. ...
In addition, the microsomal epoxide hydratase (EHm) in Hepa-1 cells is far less effective in dihydrodiol (diol) formation compared to that i …
Selective potent restriction of P450b- but not P450e-dependent 7,12-dimethylbenz[a]anthracene metabolism by the microsomal environment.
Christou M, Mitchell MJ, Jovanovich MC, Wilson NM, Jefcoate CR. Christou M, et al. Arch Biochem Biophys. 1989 Apr;270(1):162-72. doi: 10.1016/0003-9861(89)90018-0. Arch Biochem Biophys. 1989. PMID: 2494942
ACTH regulation of cholesterol movement in isolated adrenal cells.
Jefcoate CR, DiBartolomeis MJ, Williams CA, McNamara BC. Jefcoate CR, et al. J Steroid Biochem. 1987;27(4-6):721-9. doi: 10.1016/0022-4731(87)90142-7. J Steroid Biochem. 1987. PMID: 2826904
Hypercholesterolemia and the regulation of adrenal steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
DiBartolomeis MJ, Moore RW, Peterson RE, Jefcoate CR. DiBartolomeis MJ, et al. Toxicol Appl Pharmacol. 1986 Sep 30;85(3):313-23. doi: 10.1016/0041-008x(86)90338-8. Toxicol Appl Pharmacol. 1986. PMID: 3764917
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