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Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.
Park DS, Woodman SE, Schubert W, Cohen AW, Frank PG, Chandra M, Shirani J, Razani B, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP. Park DS, et al. Among authors: jelicks la. Am J Pathol. 2002 Jun;160(6):2207-17. doi: 10.1016/S0002-9440(10)61168-6. Am J Pathol. 2002. PMID: 12057923 Free PMC article.
Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts.
Cohen AW, Park DS, Woodman SE, Williams TM, Chandra M, Shirani J, Pereira de Souza A, Kitsis RN, Russell RG, Weiss LM, Tang B, Jelicks LA, Factor SM, Shtutin V, Tanowitz HB, Lisanti MP. Cohen AW, et al. Among authors: jelicks la. Am J Physiol Cell Physiol. 2003 Feb;284(2):C457-74. doi: 10.1152/ajpcell.00380.2002. Epub 2002 Oct 9. Am J Physiol Cell Physiol. 2003. PMID: 12388077 Free article.
Caveolin-1 null (-/-) mice show dramatic reductions in life span.
Park DS, Cohen AW, Frank PG, Razani B, Lee H, Williams TM, Chandra M, Shirani J, De Souza AP, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP. Park DS, et al. Among authors: jelicks la. Biochemistry. 2003 Dec 30;42(51):15124-31. doi: 10.1021/bi0356348. Biochemistry. 2003. PMID: 14690422
Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle.
Capozza F, Combs TP, Cohen AW, Cho YR, Park SY, Schubert W, Williams TM, Brasaemle DL, Jelicks LA, Scherer PE, Kim JK, Lisanti MP. Capozza F, et al. Among authors: jelicks la. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1317-31. doi: 10.1152/ajpcell.00489.2004. Epub 2005 Feb 2. Am J Physiol Cell Physiol. 2005. PMID: 15689413 Free article.
96 results