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Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.
Magkoufopoulou C, Claessen SM, Jennen DG, Kleinjans JC, van Delft JH. Magkoufopoulou C, et al. Among authors: jennen dg. Mutagenesis. 2011 Sep;26(5):593-604. doi: 10.1093/mutage/ger021. Epub 2011 Jun 1. Mutagenesis. 2011. PMID: 21632981
An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Ruiz-Aracama A, Peijnenburg A, Kleinjans J, Jennen D, van Delft J, Hellfrisch C, Lommen A. Ruiz-Aracama A, et al. BMC Genomics. 2011 May 20;12:251. doi: 10.1186/1471-2164-12-251. BMC Genomics. 2011. PMID: 21599895 Free PMC article.
Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells.
Jennen D, Ruiz-Aracama A, Magkoufopoulou C, Peijnenburg A, Lommen A, van Delft J, Kleinjans J. Jennen D, et al. BMC Syst Biol. 2011 Aug 31;5:139. doi: 10.1186/1752-0509-5-139. BMC Syst Biol. 2011. PMID: 21880148 Free PMC article.
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
Van den Hof WFPM, Coonen MLJ, van Herwijnen M, Brauers K, Jennen D, Olde Damink SWM, Schaap FG, Kleinjans JCS. Van den Hof WFPM, et al. Toxicol In Vitro. 2017 Oct;44:322-329. doi: 10.1016/j.tiv.2017.07.024. Epub 2017 Aug 1. Toxicol In Vitro. 2017. PMID: 28778767
Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study.
Souza TM, Rieswijk L, Beucken TV, Kleinjans J, Jennen D. Souza TM, et al. Toxicology. 2017 Jan 15;375:58-63. doi: 10.1016/j.tox.2016.10.009. Epub 2016 Oct 17. Toxicology. 2017. PMID: 27765683
Assessing compound carcinogenicity in vitro using connectivity mapping.
Caiment F, Tsamou M, Jennen D, Kleinjans J. Caiment F, et al. Carcinogenesis. 2014 Jan;35(1):201-7. doi: 10.1093/carcin/bgt278. Epub 2013 Aug 12. Carcinogenesis. 2014. PMID: 23940306
New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis.
Souza T, Jennen D, van Delft J, van Herwijnen M, Kyrtoupolos S, Kleinjans J. Souza T, et al. Arch Toxicol. 2016 Jun;90(6):1449-58. doi: 10.1007/s00204-015-1572-z. Epub 2015 Aug 4. Arch Toxicol. 2016. PMID: 26238291 Free PMC article.
Gender-specific transcriptomic response to environmental exposure in Flemish adults.
De Coster S, van Leeuwen DM, Jennen DG, Koppen G, Den Hond E, Nelen V, Schoeters G, Baeyens W, van Delft JH, Kleinjans JC, van Larebeke N. De Coster S, et al. Among authors: jennen dg. Environ Mol Mutagen. 2013 Aug;54(7):574-88. doi: 10.1002/em.21774. Epub 2013 May 8. Environ Mol Mutagen. 2013. PMID: 23653218
The exposome concept in a human nutrigenomics study: evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures.
van Breda SG, Wilms LC, Gaj S, Jennen DG, Briedé JJ, Kleinjans JC, de Kok TM. van Breda SG, et al. Among authors: jennen dg. Mutagenesis. 2015 Nov;30(6):723-31. doi: 10.1093/mutage/gev008. Epub 2015 Feb 22. Mutagenesis. 2015. PMID: 25711498 Review.
Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.
Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH. Jennen DG, et al. Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27. Toxicol Sci. 2010. PMID: 20106945
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