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ANCA are pathogenic--oh yes they are!
Falk RJ, Jennette JC. Falk RJ, et al. Among authors: jennette jc. J Am Soc Nephrol. 2002 Jul;13(7):1977-1979. doi: 10.1681/ASN.V1371977. J Am Soc Nephrol. 2002. PMID: 12089397 Review. No abstract available.
Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways.
Preston GA, Zarella CS, Pendergraft WF 3rd, Rudolph EH, Yang JJ, Sekura SB, Jennette JC, Falk RJ. Preston GA, et al. Among authors: jennette jc. J Am Soc Nephrol. 2002 Dec;13(12):2840-9. doi: 10.1097/01.asn.0000034911.03334.c3. J Am Soc Nephrol. 2002. PMID: 12444202
320 results