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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Jensen AA, et al. J Med Chem. 2007 Aug 23;50(17):4177-85. doi: 10.1021/jm070532r. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672447
The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.
Bräuner-Osborne H, Jensen AA, Sheppard PO, O'Hara P, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. Among authors: jensen aa. J Biol Chem. 1999 Jun 25;274(26):18382-6. doi: 10.1074/jbc.274.26.18382. J Biol Chem. 1999. PMID: 10373443
Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor.
Bräuner-Osborne H, Jensen AA, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. Among authors: jensen aa. Neuroreport. 1999 Dec 16;10(18):3923-5. doi: 10.1097/00001756-199912160-00036. Neuroreport. 1999. PMID: 10716234
Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.
Jensen AA, Spalding TA, Burstein ES, Sheppard PO, O'Hara PJ, Brann MR, Krogsgaard-Larsen P, Bräuner-Osborne H. Jensen AA, et al. J Biol Chem. 2000 Sep 22;275(38):29547-55. doi: 10.1074/jbc.M910023199. J Biol Chem. 2000. PMID: 10835431
The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity.
Jensen AA, Sheppard PO, O'Hara PJ, Krogsgaard-Larsen P, Bräuner-Osborne H. Jensen AA, et al. Eur J Pharmacol. 2000 Jun 2;397(2-3):247-53. doi: 10.1016/s0014-2999(00)00283-1. Eur J Pharmacol. 2000. PMID: 10844121
Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor.
Jensen AA, Sheppard PO, Jensen LB, O'Hara PJ, Bräuner-Osborne H. Jensen AA, et al. Among authors: jensen lb. J Biol Chem. 2001 Mar 30;276(13):10110-8. doi: 10.1074/jbc.M007220200. Epub 2000 Dec 22. J Biol Chem. 2001. PMID: 11133983
Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.
Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. Bräuner-Osborne H, et al. Among authors: jensen aa. Biochim Biophys Acta. 2001 Apr 16;1518(3):237-48. doi: 10.1016/s0167-4781(01)00197-x. Biochim Biophys Acta. 2001. PMID: 11311935
Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor.
Jensen AA, Madsen BE, Krogsgaard-Larsen P, Bräuner-Osborne H. Jensen AA, et al. Eur J Pharmacol. 2001 Apr 13;417(3):177-80. doi: 10.1016/s0014-2999(01)00918-9. Eur J Pharmacol. 2001. PMID: 11334848
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.
Jensen AA, Mosbacher J, Elg S, Lingenhoehl K, Lohmann T, Johansen TN, Abrahamsen B, Mattsson JP, Lehmann A, Bettler B, Bräuner-Osborne H. Jensen AA, et al. Mol Pharmacol. 2002 Jun;61(6):1377-84. doi: 10.1124/mol.61.6.1377. Mol Pharmacol. 2002. PMID: 12021399
Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).
Jensen AA, Hansen JL, Sheikh SP, Bräuner-Osborne H. Jensen AA, et al. Eur J Biochem. 2002 Oct;269(20):5076-87. doi: 10.1046/j.1432-1033.2002.03218.x. Eur J Biochem. 2002. PMID: 12383267
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