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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1981 2
1986 3
1987 4
1988 2
1989 3
1990 5
1991 10
1992 9
1993 9
1994 18
1995 11
1996 9
1997 15
1998 19
1999 22
2000 22
2001 37
2002 29
2003 29
2004 48
2005 56
2006 60
2007 78
2008 85
2009 98
2010 114
2011 125
2012 171
2013 218
2014 244
2015 285
2016 277
2017 307
2018 344
2019 412
2020 87
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Rejoinder
Ji L, et al. Clin Trials 2019. PMID 31581812
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
Ji L, et al. Immunity 2019. PMID 31399282
Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and arginase 1, are well-characterized hallmark molecules of classically and alternatively activated macrophages, respectively. The third metabolic fate of L-arginine is the generation of creatine that acts as a key source of cellular energy reserve, yet little is known about the role of creatine in the immune system. ...
Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and …
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