Jia R - Search Results

1

Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.

Jia R, Zhang J, Shi F, Bonomini A, Lucca C, Bertagnin C, Zhang J, Liu C, Jia H, Jiang Y, Ma X, Loregian A, Huang B, Zhan P, Liu X. Jia R, et al. Among authors: jia h. Eur J Med Chem. 2023 Apr 5;252:115275. doi: 10.1016/j.ejmech.2023.115275. Epub 2023 Mar 13. Eur J Med Chem. 2023. PMID: 36931117

2

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Zhang J, Poongavanam V, Kang D, Bertagnin C, Lu H, Kong X, Ju H, Lu X, Gao P, Tian Y, Jia H, Desta S, Ding X, Sun L, Fang Z, Huang B, Liang X, Jia R, Ma X, Xu W, Murugan NA, Loregian A, Huang B, Zhan P, Liu X. Zhang J, et al. Among authors: jia r, jia h. J Med Chem. 2018 Jul 26;61(14):6379-6397. doi: 10.1021/acs.jmedchem.8b00929. Epub 2018 Jul 16. J Med Chem. 2018. PMID: 29965752

3

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Zhang J, Murugan NA, Tian Y, Bertagnin C, Fang Z, Kang D, Kong X, Jia H, Sun Z, Jia R, Gao P, Poongavanam V, Loregian A, Xu W, Ma X, Ding X, Huang B, Zhan P, Liu X. Zhang J, et al. Among authors: jia r, jia h. J Med Chem. 2018 Nov 21;61(22):9976-9999. doi: 10.1021/acs.jmedchem.8b01065. Epub 2018 Nov 6. J Med Chem. 2018. PMID: 30365885

4

Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update).

Jia R, Zhang J, Ju H, Kang D, Fang Z, Liu X, Zhan P. Jia R, et al. Future Med Chem. 2019 Mar;11(5):375-378. doi: 10.4155/fmc-2018-0397. Epub 2019 Mar 19. Future Med Chem. 2019. PMID: 30887815 Review. No abstract available.

5

Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.

Jia R, Zhang J, Ai W, Ding X, Desta S, Sun L, Sun Z, Ma X, Li Z, Wang D, Huang B, Zhan P, Liu X. Jia R, et al. Eur J Med Chem. 2019 Sep 15;178:64-80. doi: 10.1016/j.ejmech.2019.05.076. Epub 2019 May 30. Eur J Med Chem. 2019. PMID: 31176096

6

Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.

Ju H, Xiu S, Ding X, Shang M, Jia R, Huang B, Zhan P, Liu X. Ju H, et al. Among authors: jia r. Eur J Med Chem. 2020 Feb 1;187:111940. doi: 10.1016/j.ejmech.2019.111940. Epub 2019 Dec 3. Eur J Med Chem. 2020. PMID: 31835169

7

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.

Jiang X, Wu G, Zalloum WA, Meuser ME, Dick A, Sun L, Chen CH, Kang D, Jing L, Jia R, Cocklin S, Lee KH, Liu X, Zhan P. Jiang X, et al. Among authors: jia r. RSC Adv. 2019;9(50):28961-28986. doi: 10.1039/c9ra05869a. Epub 2019 Sep 16. RSC Adv. 2019. PMID: 32089839 Free PMC article.

8

Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.

Ai W, Zhang J, Zalloum WA, Jia R, Cherukupalli S, Ding X, Sun Z, Sun L, Jiang X, Ma X, Li Z, Wang D, Huang B, Zhan P, Liu X. Ai W, et al. Among authors: jia r. Eur J Med Chem. 2020 Apr 1;191:112147. doi: 10.1016/j.ejmech.2020.112147. Epub 2020 Feb 15. Eur J Med Chem. 2020. PMID: 32092589

9

Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity.

Jia R, Zhang J, Bertagnin C, Cherukupalli S, Ai W, Ding X, Li Z, Zhang J, Ju H, Ma X, Loregian A, Huang B, Zhan P, Liu X. Jia R, et al. Eur J Med Chem. 2021 Feb 15;212:113097. doi: 10.1016/j.ejmech.2020.113097. Epub 2020 Dec 13. Eur J Med Chem. 2021. PMID: 33385836

10

Identification of C5-NH₂ Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.

Ju H, Murugan NA, Hou L, Li P, Guizzo L, Zhang Y, Bertagnin C, Kong X, Kang D, Jia R, Ma X, Du R, Poongavanam V, Loregian A, Huang B, Liu X, Zhan P. Ju H, et al. Among authors: jia r. J Med Chem. 2021 Dec 23;64(24):17992-18009. doi: 10.1021/acs.jmedchem.1c01366. Epub 2021 Nov 4. J Med Chem. 2021. PMID: 34735766

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