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Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.
Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, Martel N, Davison J, Sillaots S, Trosok S, Bachewich C, Bussey H, Youngman P, Roemer T. Xu D, et al. PLoS Pathog. 2007 Jun;3(6):e92. doi: 10.1371/journal.ppat.0030092. PLoS Pathog. 2007. PMID: 17604452 Free PMC article.
In this report, chemical-genetic relationships are provided for multiple FDA-approved antifungal drugs (fluconazole, voriconazole, caspofungin, 5-fluorocytosine, and amphotericin B) as well as additional compounds targeting ergosterol, fatty acid and sphingolipid biosynthe …
In this report, chemical-genetic relationships are provided for multiple FDA-approved antifungal drugs (fluconazole, voriconazole, caspofung …
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.
Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu W, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Pelaez F, Diez MT, Kauffman S, Becker J, Harris G, Liberator P, Roemer T. Jiang B, et al. Chem Biol. 2008 Apr;15(4):363-74. doi: 10.1016/j.chembiol.2008.02.016. Chem Biol. 2008. PMID: 18420143
Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus.
Rodriguez-Suarez R, Xu D, Veillette K, Davison J, Sillaots S, Kauffman S, Hu W, Bowman J, Martel N, Trosok S, Wang H, Zhang L, Huang LY, Li Y, Rahkhoodaee F, Ransom T, Gauvin D, Douglas C, Youngman P, Becker J, Jiang B, Roemer T. Rodriguez-Suarez R, et al. Chem Biol. 2007 Oct;14(10):1163-75. doi: 10.1016/j.chembiol.2007.09.009. Chem Biol. 2007. PMID: 17961828
Essential gene identification and drug target prioritization in Aspergillus fumigatus.
Hu W, Sillaots S, Lemieux S, Davison J, Kauffman S, Breton A, Linteau A, Xin C, Bowman J, Becker J, Jiang B, Roemer T. Hu W, et al. PLoS Pathog. 2007 Mar;3(3):e24. doi: 10.1371/journal.ppat.0030024. PLoS Pathog. 2007. PMID: 17352532 Free PMC article.
Novel strategies in antifungal lead discovery.
Jiang B, Bussey H, Roemer T. Jiang B, et al. Curr Opin Microbiol. 2002 Oct;5(5):466-71. doi: 10.1016/s1369-5274(02)00361-2. Curr Opin Microbiol. 2002. PMID: 12354552 Review.
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.
Roemer T, Jiang B, Davison J, Ketela T, Veillette K, Breton A, Tandia F, Linteau A, Sillaots S, Marta C, Martel N, Veronneau S, Lemieux S, Kauffman S, Becker J, Storms R, Boone C, Bussey H. Roemer T, et al. Mol Microbiol. 2003 Oct;50(1):167-81. doi: 10.1046/j.1365-2958.2003.03697.x. Mol Microbiol. 2003. PMID: 14507372
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
Xu D, Sillaots S, Davison J, Hu W, Jiang B, Kauffman S, Martel N, Ocampo P, Oh C, Trosok S, Veillette K, Wang H, Yang M, Zhang L, Becker J, Martin CE, Roemer T. Xu D, et al. J Biol Chem. 2009 Jul 17;284(29):19754-64. doi: 10.1074/jbc.M109.019877. Epub 2009 Jun 1. J Biol Chem. 2009. PMID: 19487691 Free PMC article.
Isolation, structure elucidation, and biological activity of virgineone from Lachnum Wirgineum using the genome-wide Candida albicans fitness test.
Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, Platas G, Collado J, Gonzáez A, de la Cruz M, Martin J, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Jiang B, Xu D, Roemer T, Singh SB. Ondeyka J, et al. J Nat Prod. 2009 Jan;72(1):136-41. doi: 10.1021/np800511r. J Nat Prod. 2009. PMID: 19115836
Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.
Parish CA, Smith SK, Calati K, Zink D, Wilson K, Roemer T, Jiang B, Xu D, Bills G, Platas G, Peláez F, Díez MT, Tsou N, McKeown AE, Ball RG, Powles MA, Yeung L, Liberator P, Harris G. Parish CA, et al. J Am Chem Soc. 2008 Jun 4;130(22):7060-6. doi: 10.1021/ja711209p. Epub 2008 May 8. J Am Chem Soc. 2008. PMID: 18461935
Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp.
Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu D, Roemer T, Singh SB. Herath K, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1361-9. doi: 10.1016/j.bmc.2008.12.009. Epub 2008 Dec 14. Bioorg Med Chem. 2009. PMID: 19112025
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