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Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Among authors: jiang y. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Dai H, Case AW, Riera TV, Considine T, Lee JE, Hamuro Y, Zhao H, Jiang Y, Sweitzer SM, Pietrak B, Schwartz B, Blum CA, Disch JS, Caldwell R, Szczepankiewicz B, Oalmann C, Yee Ng P, White BH, Casaubon R, Narayan R, Koppetsch K, Bourbonais F, Wu B, Wang J, Qian D, Jiang F, Mao C, Wang M, Hu E, Wu JC, Perni RB, Vlasuk GP, Ellis JL. Dai H, et al. Among authors: jiang f, jiang y. Nat Commun. 2015 Jul 2;6:7645. doi: 10.1038/ncomms8645. Nat Commun. 2015. PMID: 26134520 Free PMC article.
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
Diaz E, Machutta CA, Chen S, Jiang Y, Nixon C, Hofmann G, Key D, Sweitzer S, Patel M, Wu Z, Creasy CL, Kruger RG, LaFrance L, Verma SK, Pappalardi MB, Le B, Van Aller GS, McCabe MT, Tummino PJ, Pope AJ, Thrall SH, Schwartz B, Brandt M. Diaz E, et al. Among authors: jiang y. J Biomol Screen. 2012 Dec;17(10):1279-92. doi: 10.1177/1087057112453765. Epub 2012 Aug 17. J Biomol Screen. 2012. PMID: 22904200
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