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Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo.
Huang YJ, Jin MH, Pi RB, Zhang JJ, Ouyang Y, Chao XJ, Chen MH, Liu PQ, Yu JC, Ramassamy C, Dou J, Chen XH, Jiang YM, Qin J. Huang YJ, et al. Toxicol Lett. 2013 Mar 13;217(3):184-91. doi: 10.1016/j.toxlet.2012.12.023. Epub 2013 Jan 4. Toxicol Lett. 2013. PMID: 23296102
Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.
Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Drug Metab Dispos. 2014 Dec;42(12):1982-90. doi: 10.1124/dmd.114.059535. Epub 2014 Sep 12. Drug Metab Dispos. 2014. PMID: 25217484 Free PMC article.
Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine.
Fan X, Chen P, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Drug Metab Dispos. 2015 Mar;43(3):317-24. doi: 10.1124/dmd.114.062067. Epub 2014 Dec 22. Drug Metab Dispos. 2015. PMID: 25534769 Free PMC article.
Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.
Zeng H, Li D, Qin X, Chen P, Tan H, Zeng X, Li X, Fan X, Jiang Y, Zhou Y, Chen Y, Wang Y, Huang M, Bi H. Zeng H, et al. Drug Metab Dispos. 2016 Mar;44(3):337-42. doi: 10.1124/dmd.115.066969. Epub 2015 Dec 10. Drug Metab Dispos. 2016. PMID: 26658429
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