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Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan).
Li Y, Lin W, Huang J, Xie Y, Ma W. Li Y, et al. Chin Med. 2016 Sep 27;11:43. doi: 10.1186/s13020-016-0114-9. eCollection 2016. Chin Med. 2016. PMID: 27708693 Free PMC article. Review.
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-can
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of severa
Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc(Min/+) mice.
Khan I, Huang G, Li XA, Liao W, Leong WK, Xia W, Bian X, Wu J, Hsiao WLW. Khan I, et al. Pharmacol Res. 2019 Oct;148:104448. doi: 10.1016/j.phrs.2019.104448. Epub 2019 Sep 6. Pharmacol Res. 2019. PMID: 31499195
The incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the market, researchers have been searching for alternative strategies against CRC that are in demand. Therefore, we tested the cancer-pr …
The incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the …
Gypenoside L Inhibits Proliferation of Liver and Esophageal Cancer Cells by Inducing Senescence.
Ma J, Hu X, Liao C, Xiao H, Zhu Q, Li Y, Liu Z, Tao A, He Z, Xu C, Zheng K. Ma J, et al. Molecules. 2019 Mar 18;24(6):1054. doi: 10.3390/molecules24061054. Molecules. 2019. PMID: 30889805 Free PMC article.
In our study, we investigated the inhibitory effect of gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth. We found that Gyp-L increased the SA-beta-galactosidase activity, promoted the production of senescence-associated se …
In our study, we investigated the inhibitory effect of gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on c
Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview.
Li K, Ma C, Li H, Dev S, He J, Qu X. Li K, et al. Curr Top Med Chem. 2019;19(31):2855-2867. doi: 10.2174/1568026619666191114104718. Curr Top Med Chem. 2019. PMID: 31724506 Review.
Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the treatment of many diseases for a long time, and Gyps have different oral bioavailability (OB) values and lo
Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and conveni
Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).
Wang J, Yang JL, Zhou PP, Meng XH, Shi YP. Wang J, et al. J Agric Food Chem. 2017 Jul 26;65(29):5926-5934. doi: 10.1021/acs.jafc.7b01477. Epub 2017 Jul 11. J Agric Food Chem. 2017. PMID: 28662582
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. ...Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC(50) value of 8.2 0.9 muM, and moderat
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries
Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities.
Nguyen NH, Ha TKQ, Yang JL, Pham HTT, Oh WK. Nguyen NH, et al. J Ethnopharmacol. 2021 Mar 25;268:113574. doi: 10.1016/j.jep.2020.113574. Epub 2020 Nov 10. J Ethnopharmacol. 2021. PMID: 33186700 Review.
MATERIALS AND METHODS: The relevant literature on the genus Gynostemma was gathered from secondary databases (Web of Science and PubMed), books, and official websites. ...However, the promising preliminary data of other Gynostemma species indicated the research pote …
MATERIALS AND METHODS: The relevant literature on the genus Gynostemma was gathered from secondary databases (Web of Science and PubM …
Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum.
Liao W, Khan I, Huang G, Chen S, Liu L, Leong WK, Li XA, Wu J, Wendy Hsiao WL. Liao W, et al. Gut Microbes. 2020 Nov 24:1-14. doi: 10.1080/19490976.2020.1847629. Online ahead of print. Gut Microbes. 2020. PMID: 33228450
Colorectal cancer (CRC) ranks the third most common cancer type in both men and women. ...Hence, keeping a balanced gut microbiota (GM) has become a novel pursue in the medical field, particularly in the area of gastrointestinal disorders. Gynostemma pentaphy …
Colorectal cancer (CRC) ranks the third most common cancer type in both men and women. ...Hence, keeping a balanced gut microb …
Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.
Tai WC, Wong WY, Lee MM, Chan BD, Lu C, Hsiao WL. Tai WC, et al. Proteomics. 2016 May;16(10):1557-69. doi: 10.1002/pmic.201500293. Epub 2016 Apr 28. Proteomics. 2016. PMID: 26970558
Gynostemma pentaphyllum saponins (GpS) have been shown to have anti-cancer activity. ...Our findings highlight the potential of GpS as an anti-cancer agent, the potential mechanisms of its anti-cancer activities, and its effect as an adjuvant of 5-FU i
Gynostemma pentaphyllum saponins (GpS) have been shown to have anti-cancer activity. ...Our findings highlight the potential o
Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells.
Xing SF, Liu LH, Zu ML, Lin M, Zhai XF, Piao XL. Xing SF, et al. Planta Med. 2019 Mar;85(5):394-405. doi: 10.1055/a-0810-7738. Epub 2018 Dec 18. Planta Med. 2019. PMID: 30562828
In vitro, human lung cancer cells were more susceptible to damulin B treatment than human normal fibroblasts. ...Hence, damulin B has potential therapeutic efficacy against lung cancer....
In vitro, human lung cancer cells were more susceptible to damulin B treatment than human normal fibroblasts. ...Hence, damulin B has …
Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.
Song L, Chen X, Wang P, Gao S, Qu C, Liu L. Song L, et al. Acta Biochim Biophys Sin (Shanghai). 2018 Jun 1;50(6):586-596. doi: 10.1093/abbs/gmy045. Acta Biochim Biophys Sin (Shanghai). 2018. PMID: 29697746
Don, Gynostemma pentaphyllum (Thunb.) Mak and Amomum cardamomum L, i.e. Qingyihuaji (QYHJ) formula, has been shown to inhibit proliferation of pancreatic CSCs by inhibiting Shh signaling pathway and thereby prolong the overall survival of pancreatic cancer patients. …
Don, Gynostemma pentaphyllum (Thunb.) Mak and Amomum cardamomum L, i.e. Qingyihuaji (QYHJ) formula, has been shown to inhibit prolife …
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