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Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.
Jih KY, Hwang TC. Jih KY, et al. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4404-9. doi: 10.1073/pnas.1215982110. Epub 2013 Feb 25. Proc Natl Acad Sci U S A. 2013. PMID: 23440202 Free PMC article.
CFTR potentiators: from bench to bedside.
Jih KY, Lin WY, Sohma Y, Hwang TC. Jih KY, et al. Curr Opin Pharmacol. 2017 Jun;34:98-104. doi: 10.1016/j.coph.2017.09.015. Epub 2017 Nov 5. Curr Opin Pharmacol. 2017. PMID: 29073476 Free PMC article. Review.
A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.
Lin WY, Jih KY, Hwang TC. Lin WY, et al. Among authors: jih ky. J Gen Physiol. 2014 Oct;144(4):311-20. doi: 10.1085/jgp.201411247. Epub 2014 Sep 15. J Gen Physiol. 2014. PMID: 25225552 Free PMC article.
Nonequilibrium gating of CFTR on an equilibrium theme.
Jih KY, Hwang TC. Jih KY, et al. Physiology (Bethesda). 2012 Dec;27(6):351-61. doi: 10.1152/physiol.00026.2012. Physiology (Bethesda). 2012. PMID: 23223629 Free PMC article. Review.
Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.
Jih KY, Sohma Y, Hwang TC. Jih KY, et al. J Gen Physiol. 2012 Oct;140(4):347-59. doi: 10.1085/jgp.201210834. Epub 2012 Sep 10. J Gen Physiol. 2012. PMID: 22966014 Free PMC article.
Identification of a novel post-hydrolytic state in CFTR gating.
Jih KY, Sohma Y, Li M, Hwang TC. Jih KY, et al. J Gen Physiol. 2012 May;139(5):359-70. doi: 10.1085/jgp.201210789. Epub 2012 Apr 16. J Gen Physiol. 2012. PMID: 22508846 Free PMC article.
Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.
Tsai MF, Jih KY, Shimizu H, Li M, Hwang TC. Tsai MF, et al. Among authors: jih ky. J Biol Chem. 2010 Nov 26;285(48):37663-71. doi: 10.1074/jbc.M110.172817. Epub 2010 Sep 22. J Biol Chem. 2010. PMID: 20861014 Free PMC article.
The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.
Jih KY, Li M, Hwang TC, Bompadre SG. Jih KY, et al. J Physiol. 2011 Jun 1;589(Pt 11):2719-31. doi: 10.1113/jphysiol.2010.202861. Epub 2011 Apr 11. J Physiol. 2011. PMID: 21486785 Free PMC article.
Investigating CCNF mutations in a Taiwanese cohort with amyotrophic lateral sclerosis.
Tsai PC, Liao YC, Chen PL, Guo YC, Chen YH, Jih KY, Lin KP, Soong BW, Tsai CP, Lee YC. Tsai PC, et al. Among authors: jih ky. Neurobiol Aging. 2018 Feb;62:243.e1-243.e6. doi: 10.1016/j.neurobiolaging.2017.09.031. Epub 2017 Oct 9. Neurobiol Aging. 2018. PMID: 29102476
Genetic analysis of ANXA11 variants in a Han Chinese cohort with amyotrophic lateral sclerosis in Taiwan.
Tsai PC, Liao YC, Jih KY, Soong BW, Lin KP, Lee YC. Tsai PC, et al. Among authors: jih ky. Neurobiol Aging. 2018 Dec;72:188.e1-188.e2. doi: 10.1016/j.neurobiolaging.2018.07.002. Epub 2018 Jul 10. Neurobiol Aging. 2018. PMID: 30054183
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