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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Mol Cell. 2004 May 21;14(4):501-13. doi: 10.1016/s1097-2765(04)00256-4.
Mol Cell. 2004.
PMID: 15149599
Free article.
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts.
Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM.
Wei W, et al. Among authors: jobling wa.
Mol Cell Biol. 2003 Apr;23(8):2859-70. doi: 10.1128/MCB.23.8.2859-2870.2003.
Mol Cell Biol. 2003.
PMID: 12665584
Free PMC article.
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Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence.
Herbig U, Wei W, Dutriaux A, Jobling WA, Sedivy JM.
Herbig U, et al. Among authors: jobling wa.
Aging Cell. 2003 Dec;2(6):295-304. doi: 10.1046/j.1474-9728.2003.00067.x.
Aging Cell. 2003.
PMID: 14677632
Free article.
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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA.
Kujoth GC, et al. Among authors: jobling wa.
Science. 2005 Jul 15;309(5733):481-4. doi: 10.1126/science.1112125.
Science. 2005.
PMID: 16020738
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