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Synergistic drug combinations tend to improve therapeutically relevant selectivity.
Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short GF 3rd, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA. Lehár J, et al. Among authors: johansen lm. Nat Biotechnol. 2009 Jul;27(7):659-66. doi: 10.1038/nbt.1549. Epub 2009 Jul 5. Nat Biotechnol. 2009. PMID: 19581876 Free PMC article.
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.
Johansen LM, Brannan JM, Delos SE, Shoemaker CJ, Stossel A, Lear C, Hoffstrom BG, Dewald LE, Schornberg KL, Scully C, Lehár J, Hensley LE, White JM, Olinger GG. Johansen LM, et al. Sci Transl Med. 2013 Jun 19;5(190):190ra79. doi: 10.1126/scitranslmed.3005471. Sci Transl Med. 2013. PMID: 23785035 Free PMC article.
Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures.
Dyall J, Nelson EA, DeWald LE, Guha R, Hart BJ, Zhou H, Postnikova E, Logue J, Vargas WM, Gross R, Michelotti J, Deiuliis N, Bennett RS, Crozier I, Holbrook MR, Morris PJ, Klumpp-Thomas C, McKnight C, Mierzwa T, Shinn P, Glass PJ, Johansen LM, Jahrling PB, Hensley LE, Olinger GG Jr, Thomas C, White JM. Dyall J, et al. Among authors: johansen lm. J Infect Dis. 2018 Nov 22;218(suppl_5):S672-S678. doi: 10.1093/infdis/jiy304. J Infect Dis. 2018. PMID: 29939303 Free PMC article.
Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.
Herring S, Oda JM, Wagoner J, Kirchmeier D, O'Connor A, Nelson EA, Huang Q, Liang Y, DeWald LE, Johansen LM, Glass PJ, Olinger GG, Ianevski A, Aittokallio T, Paine MF, Fink SL, White JM, Polyak SJ. Herring S, et al. Among authors: johansen lm. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e01146-20. doi: 10.1128/AAC.01146-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33468464 Free PMC article.
Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo.
Finch CL, Dyall J, Xu S, Nelson EA, Postnikova E, Liang JY, Zhou H, DeWald LE, Thomas CJ, Wang A, Xu X, Hughes E, Morris PJ, Mirsalis JC, Nguyen LH, Arolfo MP, Koci B, Holbrook MR, Hensley LE, Jahrling PB, Schmaljohn C, Johansen LM, Olinger GG, Schiffer JT, White JM. Finch CL, et al. Among authors: johansen lm. Microorganisms. 2021 Mar 10;9(3):566. doi: 10.3390/microorganisms9030566. Microorganisms. 2021. PMID: 33801811 Free PMC article.
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