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C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage.
Johanssen VA, Johanssen T, Masters CL, Hill AF, Barnham KJ, Collins SJ. Johanssen VA, et al. Among authors: johanssen t. Biochem J. 2014 Apr 1;459(1):103-15. doi: 10.1042/BJ20131378. Biochem J. 2014. PMID: 24438129
Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.
Gunn AP, Wong BX, Johanssen T, Griffith JC, Masters CL, Bush AI, Barnham KJ, Duce JA, Cherny RA. Gunn AP, et al. Among authors: johanssen t. J Biol Chem. 2016 Mar 18;291(12):6134-45. doi: 10.1074/jbc.M115.655183. Epub 2015 Dec 23. J Biol Chem. 2016. PMID: 26697885 Free PMC article.
PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning.
Johanssen T, Suphantarida N, Donnelly PS, Liu XM, Petrou S, Hill AF, Barnham KJ. Johanssen T, et al. Neurobiol Dis. 2015 Sep;81:176-85. doi: 10.1016/j.nbd.2015.02.008. Epub 2015 Feb 17. Neurobiol Dis. 2015. PMID: 25697105
Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity.
Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, Lal V, Lau TL, Perez K, Curtain CC, Wade JD, Separovic F, Masters CL, Smith JP, Barnham KJ, Cappai R. Ciccotosto GD, et al. Among authors: johanssen t. Neurobiol Aging. 2011 Feb;32(2):235-48. doi: 10.1016/j.neurobiolaging.2009.02.018. Epub 2009 Mar 25. Neurobiol Aging. 2011. PMID: 19324459
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Barnham KJ, Kenche VB, Ciccotosto GD, Smith DP, Tew DJ, Liu X, Perez K, Cranston GA, Johanssen TJ, Volitakis I, Bush AI, Masters CL, White AR, Smith JP, Cherny RA, Cappai R. Barnham KJ, et al. Among authors: johanssen tj. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6813-8. doi: 10.1073/pnas.0800712105. Epub 2008 May 7. Proc Natl Acad Sci U S A. 2008. PMID: 18463291 Free PMC article.
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.
Watt AD, Perez KA, Rembach A, Sherrat NA, Hung LW, Johanssen T, McLean CA, Kok WM, Hutton CA, Fodero-Tavoletti M, Masters CL, Villemagne VL, Barnham KJ. Watt AD, et al. Among authors: johanssen t. Acta Neuropathol. 2013 Apr;125(4):549-64. doi: 10.1007/s00401-013-1083-z. Epub 2013 Jan 25. Acta Neuropathol. 2013. PMID: 23354835
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI. Duce JA, et al. Among authors: johanssen t. Cell. 2010 Sep 17;142(6):857-67. doi: 10.1016/j.cell.2010.08.014. Cell. 2010. PMID: 20817278 Free PMC article.
Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.
Smith DP, Ciccotosto GD, Tew DJ, Fodero-Tavoletti MT, Johanssen T, Masters CL, Barnham KJ, Cappai R. Smith DP, et al. Among authors: johanssen t. Biochemistry. 2007 Mar 13;46(10):2881-91. doi: 10.1021/bi0620961. Epub 2007 Feb 13. Biochemistry. 2007. PMID: 17297919